Hub : Traits

tautz: manual_spc8

Project: tautz

5 significantly associated models · 5 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 201865024 202832586 1 1 7.8e-17 3.1e-02 2.1e-10 -764 Ccs
2 18 25166673 26773279 4 1 1.3e-08 9.1e-07 1.0e+00 100 Reep5

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 4.6 4 0 0 -0.87 0.129 Reep5 Srp19 Fam13b Apc
retroperitoneal_fat_g 3.3 4 0 0 0.79 0.208 Reep5 Srp19 Fam13b Apc
body_g 8.6 4 4 200 0.91 0.088 Reep5 Srp19 Fam13b Apc
dissection: PC 2 of all traits 3.4 1 0 0 0.00 1.000 Reep5
glucose_mg_dl 7.4 4 0 0 0.53 0.472 Reep5 Srp19 Fam13b Apc
heart_g 6.1 4 0 0 0.71 0.286 Reep5 Srp19 Fam13b Apc
os_mean 7.0 4 0 0 0.87 0.127 Reep5 Srp19 Fam13b Apc
EDL weight in grams 2.4 3 0 0 0.00 1.000 Reep5 Srp19 Fam13b
Number of licking bursts 8.1 1 0 0 0.00 1.000 Ccs
Food consumed during 24 hour testing period 18.6 1 0 0 0.00 1.000 Ccs
Water consumed over 24 hour session 11.5 1 0 0 0.00 1.000 Ccs
reaction_time_peropinit_slope 8.9 3 0 0 0.00 1.000 Reep5 Srp19 Fam13b
ctth_sd 7.3 4 0 0 -0.94 0.060 Reep5 Srp19 Fam13b Apc
tautz: manual_spc9 12.9 1 0 0 0.00 1.000 Ccs
tautz: manual_mpc3 5.1 4 0 0 0.75 0.246 Reep5 Srp19 Fam13b Apc
tautz: manual_mpc4 24.6 2 1 50 0.00 1.000 Reep5 Ccs
tautz: manual_mpc5 7.6 4 0 0 0.03 0.973 Reep5 Srp19 Fam13b Apc
tautz: manual_spc22 6.9 1 0 0 0.00 1.000 Ccs
tautz: manual_mpc12 4.6 1 0 0 0.00 1.000 Reep5
tautz: manual_spc10 28.4 1 1 50 0.00 1.000 Ccs
tautz: manual_mpc2 16.6 1 0 0 0.00 1.000 Ccs
tautz: manual_spc1 24.0 1 1 50 0.00 1.000 Ccs
tautz: manual_spc16 19.8 1 0 0 0.00 1.000 Ccs
tautz: manual_mpc13 8.1 4 0 0 -0.47 0.530 Reep5 Srp19 Fam13b Apc
tautz: manual_spc5 8.9 1 0 0 0.00 1.000 Ccs
tautz: manual_mpc6 6.1 1 0 0 0.00 1.000 Ccs
tautz: manual_spc18 9.4 1 0 0 0.00 1.000 Ccs
tautz: manual_mpc11 24.9 1 1 50 0.00 1.000 Ccs
tautz: manual_spc19 5.3 2 0 0 0.00 1.000 Apc Ccs
tautz: manual_mpc1 37.0 1 1 50 0.00 1.000 Ccs
Liver selenium concentration 35.1 1 1 50 0.00 1.000 Ccs
Liver iron concentration 23.9 1 1 50 0.00 1.000 Ccs
Liver cobalt concentration 35.3 1 1 50 0.00 1.000 Ccs
Liver zinc concentration 38.0 1 1 50 0.00 1.000 Ccs
Liver sodium concentration 11.5 1 0 0 0.00 1.000 Ccs

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.5
Adipose alternative TSS 0 0.000 1.4
Adipose gene expression 0 0.000 1.4
Adipose isoform ratio 0 0.000 1.5
Adipose intron excision ratio 0 0.000 1.3
Adipose mRNA stability 0 0.000 1.4
BLA alternative polyA 0 0.000 1.6
BLA alternative TSS 0 0.000 1.3
BLA gene expression 0 0.000 1.4
BLA isoform ratio 0 0.000 1.5
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 0 0.000 1.5
Brain alternative polyA 0 0.000 1.5
Brain alternative TSS 0 0.000 1.4
Brain gene expression 0 0.000 1.4
Brain isoform ratio 0 0.000 1.5
Brain intron excision ratio 1 0.018 1.4
Brain mRNA stability 0 0.000 1.4
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.4
Eye gene expression 0 0.000 1.4
Eye isoform ratio 0 0.000 1.7
Eye intron excision ratio 0 0.000 1.2
Eye mRNA stability 0 0.000 1.5
IL alternative polyA 0 0.000 1.6
IL alternative TSS 0 0.000 1.3
IL gene expression 0 0.000 1.4
IL isoform ratio 0 0.000 1.6
IL intron excision ratio 0 0.000 1.4
IL mRNA stability 0 0.000 1.5
LHb alternative polyA 0 0.000 1.4
LHb alternative TSS 0 0.000 1.5
LHb gene expression 0 0.000 1.5
LHb isoform ratio 0 0.000 1.7
LHb intron excision ratio 0 0.000 1.4
LHb mRNA stability 0 0.000 1.6
Liver alternative polyA 0 0.000 1.5
Liver alternative TSS 0 0.000 1.3
Liver gene expression 3 0.042 1.4
Liver isoform ratio 0 0.000 1.5
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 0 0.000 1.4
NAcc alternative polyA 0 0.000 1.6
NAcc alternative TSS 0 0.000 1.6
NAcc gene expression 1 0.030 1.5
NAcc isoform ratio 0 0.000 1.7
NAcc intron excision ratio 0 0.000 1.5
NAcc mRNA stability 0 0.000 1.5
NAcc2 alternative polyA 0 0.000 1.6
NAcc2 alternative TSS 0 0.000 1.6
NAcc2 gene expression 0 0.000 1.4
NAcc2 isoform ratio 0 0.000 1.6
NAcc2 intron excision ratio 0 0.000 1.4
NAcc2 mRNA stability 0 0.000 1.5
OFC alternative polyA 0 0.000 1.6
OFC alternative TSS 0 0.000 1.5
OFC gene expression 0 0.000 1.4
OFC isoform ratio 0 0.000 1.6
OFC intron excision ratio 0 0.000 1.5
OFC mRNA stability 0 0.000 1.4
PL alternative polyA 0 0.000 1.6
PL alternative TSS 0 0.000 1.4
PL gene expression 0 0.000 1.5
PL isoform ratio 0 0.000 1.6
PL intron excision ratio 0 0.000 1.6
PL mRNA stability 0 0.000 1.5
PL2 alternative polyA 0 0.000 1.6
PL2 alternative TSS 0 0.000 1.3
PL2 gene expression 0 0.000 1.4
PL2 isoform ratio 0 0.000 1.5
PL2 intron excision ratio 0 0.000 1.4
PL2 mRNA stability 0 0.000 1.5

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.