Project: tautz
6 significantly associated models · 3 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 3 | 89760933 | 91151703 | 1 | 1 | 2.2e-07 | 2.4e-02 | 4.2e-05 | -228 | Cd59 |
| 2 | 9 | 14884566 | 16906451 | 2 | 1 | 1.6e-09 | 2.8e-10 | 2.9e-02 | 88 | Supt3h |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| dissection: UMAP 3 of all traits | 2.8 | 1 | 0 | 0 | 0.00 | 1.00000 | Supt3h |
| dissection: PC 2 of all traits | 5.0 | 2 | 0 | 0 | -0.98 | 0.00369 | Slc29a1 Supt3h |
| sol weight in grams | 4.9 | 1 | 0 | 0 | 0.00 | 1.00000 | Cd59 |
| social_reinforcement_socialrfq | 21.6 | 1 | 0 | 0 | 0.00 | 1.00000 | Cd59 |
| soc_socialavgti | 9.9 | 1 | 0 | 0 | 0.00 | 1.00000 | Cd59 |
| ctth_sd | 7.7 | 1 | 0 | 0 | 0.00 | 1.00000 | Slc29a1 |
| tautz: manual_mpc15 | 17.9 | 2 | 1 | 50 | -0.99 | 0.00121 | Slc29a1 Supt3h |
| tautz: manual_spc9 | 5.3 | 1 | 0 | 0 | 0.00 | 1.00000 | Cd59 |
| tautz: manual_mpc4 | 11.9 | 2 | 0 | 0 | -1.00 | 0.00025 | Slc29a1 Supt3h |
| tautz: manual_mcs | 5.9 | 1 | 0 | 0 | 0.00 | 1.00000 | Slc29a1 |
| tautz: manual_spc24 | 6.0 | 1 | 0 | 0 | -1.00 | 0.00168 | Supt3h |
| tautz: manual_spc10 | 11.8 | 2 | 0 | 0 | 1.00 | 0.00021 | Slc29a1 Supt3h |
| tautz: manual_spc11 | 5.7 | 1 | 0 | 0 | 0.00 | 1.00000 | Supt3h |
| tautz: manual_spc6 | 7.5 | 2 | 0 | 0 | 1.00 | 0.00020 | Slc29a1 Supt3h |
| tautz: manual_spc20 | 7.6 | 2 | 0 | 0 | 0.00 | 1.00000 | Slc29a1 Supt3h |
| Liver cobalt concentration | 6.4 | 1 | 0 | 0 | 0.00 | 1.00000 | Supt3h |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 1 | 0.047 | 1.5 |
| Adipose | alternative TSS | 0 | 0.000 | 1.4 |
| Adipose | gene expression | 0 | 0.000 | 1.5 |
| Adipose | isoform ratio | 2 | 0.071 | 1.4 |
| Adipose | intron excision ratio | 0 | 0.000 | 1.5 |
| Adipose | mRNA stability | 0 | 0.000 | 1.5 |
| BLA | alternative polyA | 0 | 0.000 | 1.6 |
| BLA | alternative TSS | 0 | 0.000 | 1.4 |
| BLA | gene expression | 0 | 0.000 | 1.5 |
| BLA | isoform ratio | 0 | 0.000 | 1.5 |
| BLA | intron excision ratio | 0 | 0.000 | 1.6 |
| BLA | mRNA stability | 0 | 0.000 | 1.5 |
| Brain | alternative polyA | 0 | 0.000 | 1.5 |
| Brain | alternative TSS | 0 | 0.000 | 1.4 |
| Brain | gene expression | 1 | 0.011 | 1.5 |
| Brain | isoform ratio | 0 | 0.000 | 1.5 |
| Brain | intron excision ratio | 0 | 0.000 | 1.6 |
| Brain | mRNA stability | 0 | 0.000 | 1.5 |
| Eye | alternative polyA | 0 | 0.000 | 1.5 |
| Eye | alternative TSS | 0 | 0.000 | 1.3 |
| Eye | gene expression | 0 | 0.000 | 1.5 |
| Eye | isoform ratio | 0 | 0.000 | 1.5 |
| Eye | intron excision ratio | 0 | 0.000 | 1.3 |
| Eye | mRNA stability | 0 | 0.000 | 1.6 |
| IL | alternative polyA | 0 | 0.000 | 1.5 |
| IL | alternative TSS | 0 | 0.000 | 1.5 |
| IL | gene expression | 0 | 0.000 | 1.5 |
| IL | isoform ratio | 0 | 0.000 | 1.5 |
| IL | intron excision ratio | 0 | 0.000 | 1.6 |
| IL | mRNA stability | 0 | 0.000 | 1.5 |
| LHb | alternative polyA | 0 | 0.000 | 1.2 |
| LHb | alternative TSS | 0 | 0.000 | 1.1 |
| LHb | gene expression | 0 | 0.000 | 1.4 |
| LHb | isoform ratio | 0 | 0.000 | 1.4 |
| LHb | intron excision ratio | 0 | 0.000 | 1.4 |
| LHb | mRNA stability | 0 | 0.000 | 1.4 |
| Liver | alternative polyA | 0 | 0.000 | 1.3 |
| Liver | alternative TSS | 0 | 0.000 | 1.4 |
| Liver | gene expression | 2 | 0.028 | 1.5 |
| Liver | isoform ratio | 0 | 0.000 | 1.3 |
| Liver | intron excision ratio | 0 | 0.000 | 1.5 |
| Liver | mRNA stability | 0 | 0.000 | 1.5 |
| NAcc | alternative polyA | 0 | 0.000 | 1.4 |
| NAcc | alternative TSS | 0 | 0.000 | 1.6 |
| NAcc | gene expression | 0 | 0.000 | 1.5 |
| NAcc | isoform ratio | 0 | 0.000 | 1.5 |
| NAcc | intron excision ratio | 0 | 0.000 | 1.5 |
| NAcc | mRNA stability | 0 | 0.000 | 1.6 |
| NAcc2 | alternative polyA | 0 | 0.000 | 1.6 |
| NAcc2 | alternative TSS | 0 | 0.000 | 1.5 |
| NAcc2 | gene expression | 0 | 0.000 | 1.5 |
| NAcc2 | isoform ratio | 0 | 0.000 | 1.5 |
| NAcc2 | intron excision ratio | 0 | 0.000 | 1.5 |
| NAcc2 | mRNA stability | 0 | 0.000 | 1.5 |
| OFC | alternative polyA | 0 | 0.000 | 1.5 |
| OFC | alternative TSS | 0 | 0.000 | 1.4 |
| OFC | gene expression | 0 | 0.000 | 1.5 |
| OFC | isoform ratio | 0 | 0.000 | 1.5 |
| OFC | intron excision ratio | 0 | 0.000 | 1.4 |
| OFC | mRNA stability | 0 | 0.000 | 1.5 |
| PL | alternative polyA | 0 | 0.000 | 1.7 |
| PL | alternative TSS | 0 | 0.000 | 1.3 |
| PL | gene expression | 0 | 0.000 | 1.5 |
| PL | isoform ratio | 0 | 0.000 | 1.5 |
| PL | intron excision ratio | 0 | 0.000 | 1.5 |
| PL | mRNA stability | 0 | 0.000 | 1.4 |
| PL2 | alternative polyA | 0 | 0.000 | 1.6 |
| PL2 | alternative TSS | 0 | 0.000 | 1.3 |
| PL2 | gene expression | 0 | 0.000 | 1.5 |
| PL2 | isoform ratio | 0 | 0.000 | 1.4 |
| PL2 | intron excision ratio | 0 | 0.000 | 1.5 |
| PL2 | mRNA stability | 0 | 0.000 | 1.5 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.