Hub : Traits

tautz: manual_spc24

Project: tautz

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 74868378 76264539 1 1 5.0e-10 0.014 5.1e-02 37 RGD1566134
2 16 5492724 6888922 1 1 7.6e-08 0.021 1.0e-13 -936 Glt8d1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
body_g 1.5 1 0 0 0 1 RGD1566134
kidney_right_g 1.8 1 0 0 0 1 Glt8d1
glucose_mg_dl 8.8 1 0 0 0 1 Glt8d1
heart_g 4.0 1 0 0 0 1 Glt8d1
os_mean 11.7 1 0 0 0 1 Glt8d1
Food consumed during 24 hour testing period 5.8 1 0 0 0 1 RGD1566134
Water consumed over 24 hour session 9.1 1 0 0 0 1 RGD1566134
light_reinforcement_lr_relactive 5.4 1 0 0 0 1 Glt8d1
light_reinforcement_lr_active 4.1 2 0 0 0 1 Glt8d1 RGD1566134
Median of all reaction times 3.7 1 0 0 0 1 RGD1566134
locomotor_testing_activity 5.2 1 0 0 0 1 Glt8d1
reaction_time_meanrt_slope 14.2 1 0 0 0 1 RGD1566134
pavca_ny_levercs_d4d5 11.9 2 1 50 0 1 Glt8d1 RGD1566134
pavca_ny_d2_magazine_cs 15.7 1 0 0 0 1 RGD1566134
ccp_trial_3_saline_dist_mm 5.1 1 0 0 0 1 Glt8d1
pavca_ny_d5_magazine_ncs 7.6 1 0 0 0 1 RGD1566134
ccp_change_in_locomotor_activity 6.1 1 0 0 0 1 RGD1566134
Total sessions with >9 infusions 13.2 2 0 0 0 1 Glt8d1 RGD1566134
crf_mi_active_responses 13.3 1 0 0 0 1 RGD1566134
Total cortical area 6.6 1 0 0 0 1 RGD1566134
length 3.0 1 0 0 0 1 RGD1566134
ctth_sd 4.8 2 0 0 0 1 Glt8d1 RGD1566134
tautz: manual_spc7 6.4 1 0 0 0 1 RGD1566134
tautz: manual_mpc15 5.5 1 0 0 0 1 RGD1566134
tautz: manual_mpc18 6.0 1 0 0 0 1 Glt8d1
tautz: manual_spc12 5.9 1 0 0 0 1 RGD1566134
tautz: manual_mpc7 14.1 2 1 50 0 1 Glt8d1 RGD1566134
tautz: manual_mpc10 4.3 1 0 0 0 1 RGD1566134
tautz: manual_mpc5 12.3 1 0 0 0 1 RGD1566134
tautz: manual_spc22 4.9 2 0 0 0 1 Glt8d1 RGD1566134
tautz: manual_mpc14 6.5 1 0 0 0 1 RGD1566134
tautz: manual_mpc12 9.5 1 0 0 0 1 RGD1566134
tautz: manual_mcs 6.9 1 0 0 0 1 RGD1566134
tautz: manual_spc17 6.5 1 0 0 0 1 RGD1566134
tautz: manual_spc4 13.3 2 0 0 0 1 Glt8d1 RGD1566134
tautz: manual_mpc19 4.5 1 0 0 0 1 Glt8d1
tautz: manual_spc10 8.2 2 0 0 0 1 Glt8d1 RGD1566134
tautz: manual_spc11 6.7 1 0 0 0 1 Glt8d1
tautz: manual_spc6 11.4 1 0 0 0 1 RGD1566134
tautz: manual_spc20 7.8 1 0 0 0 1 RGD1566134
tautz: manual_mpc2 21.7 1 0 0 0 1 Glt8d1
tautz: manual_mpc13 5.7 1 0 0 0 1 RGD1566134
tautz: manual_spc5 32.5 1 1 50 0 1 RGD1566134
tautz: manual_mpc6 24.2 1 1 50 0 1 RGD1566134
tautz: manual_mpc11 8.5 2 0 0 0 1 Glt8d1 RGD1566134
tautz: manual_mpc1 6.6 2 0 0 0 1 Glt8d1 RGD1566134
The total number of resting periods in time1 6.4 1 0 0 0 1 Glt8d1
Weight adjusted by age 7.9 1 0 0 0 1 RGD1566134
Liver rubidium concentration 5.2 1 0 0 0 1 RGD1566134
Liver iron concentration 8.7 1 0 0 0 1 RGD1566134
Liver cadmium concentration 5.1 1 0 0 0 1 RGD1566134
Liver zinc concentration 10.3 2 0 0 0 1 Glt8d1 RGD1566134
Liver sodium concentration 15.7 1 0 0 0 1 RGD1566134

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.4
Adipose alternative TSS 0 0.000 1.5
Adipose gene expression 1 0.012 1.4
Adipose isoform ratio 0 0.000 1.4
Adipose intron excision ratio 0 0.000 1.3
Adipose mRNA stability 0 0.000 1.4
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.6
BLA gene expression 0 0.000 1.4
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 0 0.000 1.4
Brain alternative polyA 0 0.000 1.4
Brain alternative TSS 0 0.000 1.5
Brain gene expression 0 0.000 1.4
Brain isoform ratio 0 0.000 1.4
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.4
Eye alternative polyA 0 0.000 1.2
Eye alternative TSS 0 0.000 1.4
Eye gene expression 0 0.000 1.4
Eye isoform ratio 0 0.000 1.4
Eye intron excision ratio 0 0.000 1.2
Eye mRNA stability 0 0.000 1.6
IL alternative polyA 0 0.000 1.2
IL alternative TSS 0 0.000 1.4
IL gene expression 0 0.000 1.4
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.4
IL mRNA stability 0 0.000 1.5
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.3
LHb gene expression 0 0.000 1.4
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 0 0.000 1.2
LHb mRNA stability 0 0.000 1.4
Liver alternative polyA 0 0.000 1.4
Liver alternative TSS 0 0.000 1.5
Liver gene expression 0 0.000 1.4
Liver isoform ratio 0 0.000 1.4
Liver intron excision ratio 1 0.023 1.4
Liver mRNA stability 0 0.000 1.5
NAcc alternative polyA 0 0.000 1.1
NAcc alternative TSS 0 0.000 1.4
NAcc gene expression 0 0.000 1.4
NAcc isoform ratio 0 0.000 1.3
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.4
NAcc2 alternative polyA 0 0.000 1.4
NAcc2 alternative TSS 0 0.000 1.4
NAcc2 gene expression 0 0.000 1.4
NAcc2 isoform ratio 0 0.000 1.5
NAcc2 intron excision ratio 0 0.000 1.4
NAcc2 mRNA stability 0 0.000 1.4
OFC alternative polyA 0 0.000 1.2
OFC alternative TSS 0 0.000 1.4
OFC gene expression 0 0.000 1.4
OFC isoform ratio 0 0.000 1.4
OFC intron excision ratio 0 0.000 1.4
OFC mRNA stability 0 0.000 1.4
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.3
PL gene expression 0 0.000 1.4
PL isoform ratio 0 0.000 1.3
PL intron excision ratio 0 0.000 1.3
PL mRNA stability 0 0.000 1.4
PL2 alternative polyA 0 0.000 1.3
PL2 alternative TSS 0 0.000 1.5
PL2 gene expression 0 0.000 1.4
PL2 isoform ratio 0 0.000 1.4
PL2 intron excision ratio 0 0.000 1.4
PL2 mRNA stability 0 0.000 1.4

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.