Hub : Traits

tautz: manual_spc21

Project: tautz

20 significantly associated models · 6 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 179109719 181703913 6 1 9.6e-08 1.8e-07 1 100 Mrps35

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Tibia length in mm 3.6 6 0 0 1 3.2e-27 Mrps35 Klhl42 Ccdc91 Far2 Ppfibp1 NA
tautz: manual_mpc5 8.1 2 0 0 0 1.0e+00 Mrps35 Klhl42
tautz: manual_spc22 7.5 6 0 0 -1 2.9e-30 Mrps35 Klhl42 Ccdc91 Far2 Ppfibp1 NA
tautz: manual_mpc12 8.0 6 0 0 1 2.8e-25 Mrps35 Klhl42 Ccdc91 Far2 Ppfibp1 NA
tautz: manual_spc17 7.6 5 0 0 1 2.1e-25 Mrps35 Klhl42 Ccdc91 Ppfibp1 NA
tautz: manual_spc11 11.6 6 0 0 1 7.2e-28 Mrps35 Klhl42 Ccdc91 Far2 Ppfibp1 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 1 0.062 1.3
Adipose gene expression 1 0.012 1.3
Adipose isoform ratio 1 0.035 1.3
Adipose intron excision ratio 4 0.137 1.3
Adipose mRNA stability 0 0.000 1.2
BLA alternative polyA 0 0.000 1.3
BLA alternative TSS 0 0.000 1.4
BLA gene expression 1 0.016 1.2
BLA isoform ratio 0 0.000 1.3
BLA intron excision ratio 0 0.000 1.2
BLA mRNA stability 0 0.000 1.3
Brain alternative polyA 0 0.000 1.3
Brain alternative TSS 0 0.000 1.4
Brain gene expression 0 0.000 1.2
Brain isoform ratio 0 0.000 1.3
Brain intron excision ratio 1 0.018 1.2
Brain mRNA stability 0 0.000 1.2
Eye alternative polyA 0 0.000 1.1
Eye alternative TSS 0 0.000 1.3
Eye gene expression 1 0.089 1.3
Eye isoform ratio 0 0.000 1.2
Eye intron excision ratio 0 0.000 1.0
Eye mRNA stability 0 0.000 1.2
IL alternative polyA 0 0.000 1.3
IL alternative TSS 0 0.000 1.2
IL gene expression 0 0.000 1.2
IL isoform ratio 0 0.000 1.2
IL intron excision ratio 0 0.000 1.3
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.3
LHb gene expression 1 0.031 1.2
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 1 0.097 1.2
LHb mRNA stability 0 0.000 1.3
Liver alternative polyA 0 0.000 1.2
Liver alternative TSS 0 0.000 1.2
Liver gene expression 0 0.000 1.3
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 0 0.000 1.2
NAcc alternative polyA 0 0.000 1.3
NAcc alternative TSS 0 0.000 1.3
NAcc gene expression 3 0.091 1.3
NAcc isoform ratio 0 0.000 1.2
NAcc intron excision ratio 0 0.000 1.1
NAcc mRNA stability 0 0.000 1.3
NAcc2 alternative polyA 0 0.000 1.3
NAcc2 alternative TSS 0 0.000 1.2
NAcc2 gene expression 1 0.019 1.2
NAcc2 isoform ratio 0 0.000 1.3
NAcc2 intron excision ratio 0 0.000 1.2
NAcc2 mRNA stability 0 0.000 1.3
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.3
OFC gene expression 1 0.027 1.3
OFC isoform ratio 0 0.000 1.2
OFC intron excision ratio 1 0.099 1.4
OFC mRNA stability 1 0.093 1.3
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.4
PL gene expression 1 0.027 1.2
PL isoform ratio 0 0.000 1.2
PL intron excision ratio 0 0.000 1.3
PL mRNA stability 0 0.000 1.2
PL2 alternative polyA 0 0.000 1.3
PL2 alternative TSS 0 0.000 1.3
PL2 gene expression 0 0.000 1.2
PL2 isoform ratio 0 0.000 1.3
PL2 intron excision ratio 0 0.000 1.2
PL2 mRNA stability 0 0.000 1.3

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.