Project: tautz
35 significantly associated models · 16 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 7254793 | 8653308 | 1 | 1 | 2.5e-07 | 2.3e-06 | 0.48 | 98 | Adat2 |
| 2 | 10 | 90616754 | 92013965 | 1 | 1 | 2.6e-08 | 1.5e-06 | 0.91 | 100 | Icam2 |
| 3 | 10 | 92191656 | 96071622 | 14 | 6 | 6.1e-09 | 1.7e-07 | NaN | NaN | Prkca Apoh Wipi1 Abca8a Map2k6 NA |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| body_g | 2.4 | 2 | 0 | 0 | 0 | 1.0e+00 | Apoh Wipi1 |
| heart_g | 7.9 | 1 | 0 | 0 | 0 | 1.0e+00 | Wipi1 |
| TA weight in grams | 7.5 | 1 | 0 | 0 | 0 | 1.0e+00 | Adat2 |
| ccp_trial_3_saline_dist_mm | 9.9 | 1 | 0 | 0 | 0 | 1.0e+00 | Map2k6 |
| Total cortical area | 20.8 | 15 | 15 | 188 | 1 | 5.4e-34 | Prkca Apoh Rgs9 Wipi1 Arsg Fam20a Abca8 Abca8a Map2k6 Icam2 Prkar1a AABR07030630.1 Abca9 NA NA |
| tautz: manual_spc9 | 7.7 | 2 | 0 | 0 | 0 | 1.0e+00 | Map2k6 NA |
| tautz: manual_spc14 | 7.7 | 1 | 0 | 0 | 0 | 1.0e+00 | Map2k6 |
| tautz: manual_mpc6 | 10.1 | 1 | 0 | 0 | 0 | 1.0e+00 | Wipi1 |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 0 | 0.000 | 1.5 |
| Adipose | alternative TSS | 0 | 0.000 | 1.4 |
| Adipose | gene expression | 2 | 0.024 | 1.5 |
| Adipose | isoform ratio | 0 | 0.000 | 1.5 |
| Adipose | intron excision ratio | 2 | 0.069 | 1.5 |
| Adipose | mRNA stability | 0 | 0.000 | 1.5 |
| BLA | alternative polyA | 0 | 0.000 | 1.5 |
| BLA | alternative TSS | 0 | 0.000 | 1.6 |
| BLA | gene expression | 3 | 0.049 | 1.5 |
| BLA | isoform ratio | 2 | 0.114 | 1.4 |
| BLA | intron excision ratio | 1 | 0.033 | 1.5 |
| BLA | mRNA stability | 0 | 0.000 | 1.5 |
| Brain | alternative polyA | 0 | 0.000 | 1.5 |
| Brain | alternative TSS | 0 | 0.000 | 1.5 |
| Brain | gene expression | 2 | 0.022 | 1.5 |
| Brain | isoform ratio | 0 | 0.000 | 1.5 |
| Brain | intron excision ratio | 0 | 0.000 | 1.5 |
| Brain | mRNA stability | 1 | 0.023 | 1.5 |
| Eye | alternative polyA | 0 | 0.000 | 1.6 |
| Eye | alternative TSS | 0 | 0.000 | 1.6 |
| Eye | gene expression | 1 | 0.089 | 1.5 |
| Eye | isoform ratio | 0 | 0.000 | 1.4 |
| Eye | intron excision ratio | 0 | 0.000 | 1.6 |
| Eye | mRNA stability | 0 | 0.000 | 1.3 |
| IL | alternative polyA | 0 | 0.000 | 1.4 |
| IL | alternative TSS | 0 | 0.000 | 1.4 |
| IL | gene expression | 1 | 0.027 | 1.5 |
| IL | isoform ratio | 0 | 0.000 | 1.3 |
| IL | intron excision ratio | 0 | 0.000 | 1.6 |
| IL | mRNA stability | 1 | 0.090 | 1.5 |
| LHb | alternative polyA | 0 | 0.000 | 1.4 |
| LHb | alternative TSS | 0 | 0.000 | 1.4 |
| LHb | gene expression | 1 | 0.031 | 1.5 |
| LHb | isoform ratio | 0 | 0.000 | 1.4 |
| LHb | intron excision ratio | 1 | 0.097 | 1.6 |
| LHb | mRNA stability | 0 | 0.000 | 1.5 |
| Liver | alternative polyA | 0 | 0.000 | 1.6 |
| Liver | alternative TSS | 0 | 0.000 | 1.6 |
| Liver | gene expression | 3 | 0.042 | 1.5 |
| Liver | isoform ratio | 0 | 0.000 | 1.5 |
| Liver | intron excision ratio | 0 | 0.000 | 1.5 |
| Liver | mRNA stability | 0 | 0.000 | 1.5 |
| NAcc | alternative polyA | 0 | 0.000 | 1.5 |
| NAcc | alternative TSS | 0 | 0.000 | 1.5 |
| NAcc | gene expression | 2 | 0.061 | 1.5 |
| NAcc | isoform ratio | 0 | 0.000 | 1.3 |
| NAcc | intron excision ratio | 0 | 0.000 | 1.4 |
| NAcc | mRNA stability | 0 | 0.000 | 1.5 |
| NAcc2 | alternative polyA | 0 | 0.000 | 1.4 |
| NAcc2 | alternative TSS | 0 | 0.000 | 1.5 |
| NAcc2 | gene expression | 3 | 0.056 | 1.5 |
| NAcc2 | isoform ratio | 0 | 0.000 | 1.4 |
| NAcc2 | intron excision ratio | 0 | 0.000 | 1.5 |
| NAcc2 | mRNA stability | 1 | 0.056 | 1.6 |
| OFC | alternative polyA | 0 | 0.000 | 1.4 |
| OFC | alternative TSS | 0 | 0.000 | 1.5 |
| OFC | gene expression | 2 | 0.054 | 1.5 |
| OFC | isoform ratio | 0 | 0.000 | 1.4 |
| OFC | intron excision ratio | 0 | 0.000 | 1.6 |
| OFC | mRNA stability | 0 | 0.000 | 1.5 |
| PL | alternative polyA | 0 | 0.000 | 1.5 |
| PL | alternative TSS | 0 | 0.000 | 1.5 |
| PL | gene expression | 2 | 0.054 | 1.5 |
| PL | isoform ratio | 0 | 0.000 | 1.5 |
| PL | intron excision ratio | 0 | 0.000 | 1.6 |
| PL | mRNA stability | 0 | 0.000 | 1.5 |
| PL2 | alternative polyA | 0 | 0.000 | 1.6 |
| PL2 | alternative TSS | 1 | 0.106 | 1.4 |
| PL2 | gene expression | 1 | 0.016 | 1.5 |
| PL2 | isoform ratio | 0 | 0.000 | 1.5 |
| PL2 | intron excision ratio | 0 | 0.000 | 1.4 |
| PL2 | mRNA stability | 2 | 0.082 | 1.5 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.