Hub : Traits

tautz: manual_mpc7

Project: tautz

5 significantly associated models · 4 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 34540819 36920918 2 1 9.8e-09 5.3e-07 0.332 96 Nln
2 5 74868378 76264539 1 1 1.6e-07 1.1e-03 0.084 72 RGD1566134
3 13 65203726 66599027 1 1 6.7e-08 9.9e-03 0.082 54 Rnasel

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
body_g 1.8 1 0 0 0 1 Nln
dissection: UMAP 3 of all traits 6.8 2 0 0 0 1 Nln Rgs7bp
dissection: PC 3 of all traits 5.1 2 0 0 0 1 Nln Rgs7bp
dissection: PC 2 of all traits 7.4 2 0 0 0 1 Nln Rgs7bp
os_mean 6.1 1 0 0 0 1 Nln
EDL weight in grams 4.3 2 0 0 0 1 Nln Rgs7bp
Tibia length in mm 5.6 2 0 0 0 1 Nln Rgs7bp
sol weight in grams 3.5 1 0 0 0 1 Rnasel
TA weight in grams 2.4 2 0 0 0 1 Nln Rgs7bp
Food consumed during 24 hour testing period 5.8 1 0 0 0 1 RGD1566134
Water consumed over 24 hour session 9.1 1 0 0 0 1 RGD1566134
Delay discounting water rate 0 sec 4.2 1 0 0 0 1 Nln
reaction_time_corr 7.9 2 0 0 0 1 Nln Rgs7bp
reaction_time_leftcorr 7.9 2 0 0 0 1 Nln Rgs7bp
reaction_time_pinit 11.6 2 0 0 0 1 Nln Rgs7bp
reaction_time_pinit_slope 9.0 2 0 0 0 1 Nln Rgs7bp
reaction_time_meanrt_slope 14.2 1 0 0 0 1 RGD1566134
pavca_ny_levercs_d4d5 19.1 1 1 33 0 1 RGD1566134
pavca_ny_d2_magazine_cs 15.7 1 0 0 0 1 RGD1566134
pavca_ny_d5_magazine_ncs 7.6 1 0 0 0 1 RGD1566134
ccp_change_in_locomotor_activity 6.1 1 0 0 0 1 RGD1566134
Total sessions with >9 infusions 15.1 1 0 0 0 1 RGD1566134
crf_mi_active_responses 13.3 1 0 0 0 1 RGD1566134
pavca_mi_d1_prob_lev 5.0 2 0 0 0 1 Nln Rgs7bp
pavca_mi_d3_prob_mag 6.0 1 0 0 0 1 Rnasel
Total cortical area 6.6 1 0 0 0 1 RGD1566134
length 5.5 2 0 0 0 1 Nln Rgs7bp
Trabecular tissue density 6.4 1 0 0 0 1 Rnasel
tautz: manual_spc7 6.4 1 0 0 0 1 RGD1566134
tautz: manual_mpc15 5.5 1 0 0 0 1 RGD1566134
tautz: manual_spc9 5.7 2 0 0 0 1 Nln Rgs7bp
tautz: manual_mpc3 8.5 2 0 0 0 1 Nln Rgs7bp
tautz: manual_spc12 5.9 1 0 0 0 1 RGD1566134
tautz: manual_spc14 4.8 2 0 0 0 1 Nln Rgs7bp
tautz: manual_mpc5 12.3 1 0 0 0 1 RGD1566134
tautz: manual_mpc14 6.5 1 0 0 0 1 RGD1566134
tautz: manual_mpc12 9.5 1 0 0 0 1 RGD1566134
tautz: manual_mcs 6.9 1 0 0 0 1 RGD1566134
tautz: manual_spc17 6.5 1 0 0 0 1 RGD1566134
tautz: manual_spc24 27.7 1 1 33 0 1 RGD1566134
tautz: manual_spc4 11.3 2 0 0 0 1 Nln RGD1566134
tautz: manual_mpc9 5.5 2 0 0 0 1 Nln Rgs7bp
tautz: manual_spc10 9.2 1 0 0 0 1 RGD1566134
tautz: manual_spc11 8.2 2 0 0 0 1 Nln Rgs7bp
tautz: manual_spc6 11.4 1 0 0 0 1 RGD1566134
tautz: manual_spc20 7.0 2 0 0 0 1 Nln RGD1566134
tautz: manual_spc1 7.9 2 0 0 0 1 Nln Rgs7bp
tautz: manual_mpc13 5.7 1 0 0 0 1 RGD1566134
tautz: manual_spc5 19.1 2 1 33 0 1 Nln RGD1566134
tautz: manual_mpc6 24.2 1 1 33 0 1 RGD1566134
tautz: manual_mpc1 8.5 1 0 0 0 1 RGD1566134
Weight adjusted by age 7.9 1 0 0 0 1 RGD1566134
Liver iron concentration 8.7 1 0 0 0 1 RGD1566134
Liver zinc concentration 15.1 1 0 0 0 1 RGD1566134
Liver sodium concentration 15.7 1 0 0 0 1 RGD1566134

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.28
Adipose alternative TSS 0 0.000 1.25
Adipose gene expression 0 0.000 1.22
Adipose isoform ratio 0 0.000 1.27
Adipose intron excision ratio 0 0.000 1.14
Adipose mRNA stability 0 0.000 1.21
BLA alternative polyA 0 0.000 1.14
BLA alternative TSS 0 0.000 1.06
BLA gene expression 0 0.000 1.16
BLA isoform ratio 0 0.000 1.12
BLA intron excision ratio 0 0.000 1.08
BLA mRNA stability 0 0.000 1.16
Brain alternative polyA 1 0.050 1.28
Brain alternative TSS 0 0.000 1.15
Brain gene expression 1 0.011 1.18
Brain isoform ratio 0 0.000 1.17
Brain intron excision ratio 0 0.000 1.10
Brain mRNA stability 0 0.000 1.15
Eye alternative polyA 0 0.000 1.13
Eye alternative TSS 0 0.000 1.12
Eye gene expression 0 0.000 1.13
Eye isoform ratio 0 0.000 1.14
Eye intron excision ratio 0 0.000 1.06
Eye mRNA stability 0 0.000 1.17
IL alternative polyA 0 0.000 1.16
IL alternative TSS 0 0.000 1.08
IL gene expression 1 0.027 1.19
IL isoform ratio 0 0.000 1.26
IL intron excision ratio 0 0.000 1.12
IL mRNA stability 0 0.000 1.19
LHb alternative polyA 0 0.000 1.23
LHb alternative TSS 0 0.000 1.12
LHb gene expression 0 0.000 1.19
LHb isoform ratio 0 0.000 1.19
LHb intron excision ratio 0 0.000 1.13
LHb mRNA stability 0 0.000 1.19
Liver alternative polyA 0 0.000 1.23
Liver alternative TSS 0 0.000 1.25
Liver gene expression 1 0.014 1.22
Liver isoform ratio 0 0.000 1.28
Liver intron excision ratio 1 0.023 1.26
Liver mRNA stability 0 0.000 1.24
NAcc alternative polyA 0 0.000 1.12
NAcc alternative TSS 0 0.000 1.26
NAcc gene expression 0 0.000 1.16
NAcc isoform ratio 0 0.000 1.10
NAcc intron excision ratio 0 0.000 1.13
NAcc mRNA stability 0 0.000 1.20
NAcc2 alternative polyA 0 0.000 1.25
NAcc2 alternative TSS 0 0.000 1.25
NAcc2 gene expression 0 0.000 1.13
NAcc2 isoform ratio 0 0.000 1.20
NAcc2 intron excision ratio 0 0.000 1.10
NAcc2 mRNA stability 0 0.000 1.10
OFC alternative polyA 0 0.000 1.04
OFC alternative TSS 0 0.000 0.97
OFC gene expression 0 0.000 1.15
OFC isoform ratio 0 0.000 1.18
OFC intron excision ratio 0 0.000 1.19
OFC mRNA stability 0 0.000 1.20
PL alternative polyA 0 0.000 1.12
PL alternative TSS 0 0.000 1.03
PL gene expression 0 0.000 1.22
PL isoform ratio 0 0.000 1.15
PL intron excision ratio 0 0.000 1.06
PL mRNA stability 0 0.000 1.24
PL2 alternative polyA 0 0.000 1.25
PL2 alternative TSS 0 0.000 1.06
PL2 gene expression 0 0.000 1.16
PL2 isoform ratio 0 0.000 1.11
PL2 intron excision ratio 0 0.000 1.02
PL2 mRNA stability 0 0.000 1.14

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.