Hub : Traits

tautz: manual_mpc4

Project: tautz

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 6.4e-08 0.030 2.2e-10 -754 Syt5
2 1 201865024 202832586 1 1 3.5e-13 0.019 1.0e+00 100 Ccs

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
body_g 2.6 1 0 0 0 1 Syt5
dissection: UMAP 3 of all traits 3.0 1 0 0 0 1 Syt5
kidney_right_g 2.6 1 0 0 0 1 Syt5
glucose_mg_dl 12.1 1 0 0 0 1 Syt5
Tibia length in mm 7.5 1 0 0 0 1 Syt5
TA weight in grams 2.4 1 0 0 0 1 Syt5
Std. dev. time between licks in bursts 22.8 1 1 50 0 1 Syt5
Number of licking bursts 8.1 1 0 0 0 1 Ccs
Food consumed during 24 hour testing period 18.6 1 0 0 0 1 Ccs
Water consumed over 24 hour session 11.5 1 0 0 0 1 Ccs
Average drop size 8.6 2 0 0 0 1 Syt5 Ccs
light_reinforcement_lr_relactive 21.5 1 1 50 0 1 Syt5
light_reinforcement_lr_active 21.5 1 1 50 0 1 Syt5
Delay discounting water rate 0 sec 10.3 1 0 0 0 1 Syt5
Median of all reaction times 7.0 1 0 0 0 1 Syt5
social_reinforcement_socialrfq 8.0 1 0 0 0 1 Syt5
reaction_time_pinit_slope 9.7 1 0 0 0 1 Syt5
reaction_time_peropfalsealarm_slope 11.6 1 0 0 0 1 Syt5
reaction_time_meanrt_slope 15.7 1 0 0 0 1 Syt5
reaction_time_devmedrt_slope 42.2 1 1 50 0 1 Syt5
ccp_trial_3_saline_dist_mm 23.3 1 1 50 0 1 Syt5
ccp_change_in_locomotor_activity 5.9 1 0 0 0 1 Syt5
Conditioned locomotion 15.1 1 0 0 0 1 Syt5
pavca_mi_d1_avg_mag_lat 5.4 1 0 0 0 1 Syt5
pavca_mi_d3_magazine_ncs 5.2 1 0 0 0 1 Syt5
tb_th_sd 6.3 1 0 0 0 1 Syt5
Trabecular tissue density 8.2 1 0 0 0 1 Syt5
ctth_sd 7.8 1 0 0 0 1 Syt5
tautz: manual_mpc18 7.6 1 0 0 0 1 Syt5
tautz: manual_spc15 11.6 1 0 0 0 1 Syt5
tautz: manual_spc21 5.5 1 0 0 0 1 Syt5
tautz: manual_spc9 18.5 2 1 50 0 1 Syt5 Ccs
tautz: manual_mpc3 8.8 1 0 0 0 1 Syt5
tautz: manual_spc12 20.2 1 1 50 0 1 Syt5
tautz: manual_spc14 8.9 1 0 0 0 1 Syt5
tautz: manual_spc8 48.6 1 1 50 0 1 Ccs
tautz: manual_mpc7 6.5 1 0 0 0 1 Syt5
tautz: manual_mpc10 7.8 1 0 0 0 1 Syt5
tautz: manual_mpc5 23.6 1 1 50 0 1 Syt5
tautz: manual_spc22 38.3 2 1 50 0 1 Syt5 Ccs
tautz: manual_mpc12 25.5 1 1 50 0 1 Syt5
tautz: manual_mcs 4.9 1 0 0 0 1 Ccs
tautz: manual_spc24 8.0 1 0 0 0 1 Syt5
tautz: manual_mpc19 32.6 1 1 50 0 1 Syt5
tautz: manual_spc10 23.8 2 1 50 0 1 Syt5 Ccs
tautz: manual_spc23 10.7 1 0 0 0 1 Syt5
tautz: manual_spc6 26.8 2 1 50 0 1 Syt5 Ccs
tautz: manual_mpc2 16.6 1 0 0 0 1 Ccs
tautz: manual_spc1 17.4 2 1 50 0 1 Syt5 Ccs
tautz: manual_spc16 12.5 2 0 0 0 1 Syt5 Ccs
tautz: manual_spc5 13.4 2 0 0 0 1 Syt5 Ccs
tautz: manual_spc3 11.2 1 0 0 0 1 Syt5
tautz: manual_mpc6 6.1 1 0 0 0 1 Ccs
tautz: manual_spc18 9.4 1 0 0 0 1 Ccs
tautz: manual_mpc11 24.9 1 1 50 0 1 Ccs
tautz: manual_spc19 8.9 2 0 0 0 1 Syt5 Ccs
tautz: manual_mpc1 37.0 1 1 50 0 1 Ccs
Sum of all infusions from LGA sessions 5.8 1 0 0 0 1 Syt5
Ambulatory time at time1 of open field 36.6 1 1 50 0 1 Syt5
The total number of resting periods in time1 37.4 1 1 50 0 1 Syt5
punishment 133.8 1 1 50 0 1 Syt5
Weight adjusted by age 8.2 1 0 0 0 1 Syt5
Liver selenium concentration 35.1 1 1 50 0 1 Ccs
Liver rubidium concentration 6.5 1 0 0 0 1 Syt5
Liver iron concentration 23.9 1 1 50 0 1 Ccs
Liver cobalt concentration 27.4 2 1 50 0 1 Syt5 Ccs
Liver cadmium concentration 6.7 2 0 0 0 1 Syt5 Ccs
Liver zinc concentration 25.2 2 1 50 0 1 Syt5 Ccs
Liver sodium concentration 11.5 1 0 0 0 1 Ccs
Liver manganese concentration 4.7 1 0 0 0 1 Ccs

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.22
Adipose alternative TSS 0 0.000 1.12
Adipose gene expression 0 0.000 1.26
Adipose isoform ratio 0 0.000 1.22
Adipose intron excision ratio 0 0.000 1.24
Adipose mRNA stability 0 0.000 1.25
BLA alternative polyA 0 0.000 1.16
BLA alternative TSS 0 0.000 1.24
BLA gene expression 0 0.000 1.25
BLA isoform ratio 0 0.000 1.15
BLA intron excision ratio 0 0.000 1.16
BLA mRNA stability 1 0.049 1.28
Brain alternative polyA 0 0.000 1.26
Brain alternative TSS 0 0.000 1.20
Brain gene expression 0 0.000 1.25
Brain isoform ratio 0 0.000 1.22
Brain intron excision ratio 0 0.000 1.23
Brain mRNA stability 0 0.000 1.23
Eye alternative polyA 0 0.000 0.89
Eye alternative TSS 0 0.000 0.99
Eye gene expression 0 0.000 1.23
Eye isoform ratio 0 0.000 1.10
Eye intron excision ratio 0 0.000 1.13
Eye mRNA stability 0 0.000 1.22
IL alternative polyA 0 0.000 1.15
IL alternative TSS 0 0.000 0.97
IL gene expression 0 0.000 1.24
IL isoform ratio 0 0.000 1.06
IL intron excision ratio 0 0.000 1.15
IL mRNA stability 0 0.000 1.29
LHb alternative polyA 0 0.000 1.10
LHb alternative TSS 0 0.000 1.03
LHb gene expression 0 0.000 1.24
LHb isoform ratio 0 0.000 1.20
LHb intron excision ratio 0 0.000 1.14
LHb mRNA stability 0 0.000 1.20
Liver alternative polyA 0 0.000 1.21
Liver alternative TSS 0 0.000 1.14
Liver gene expression 1 0.014 1.27
Liver isoform ratio 0 0.000 1.21
Liver intron excision ratio 0 0.000 1.30
Liver mRNA stability 0 0.000 1.29
NAcc alternative polyA 0 0.000 1.03
NAcc alternative TSS 0 0.000 1.23
NAcc gene expression 0 0.000 1.24
NAcc isoform ratio 0 0.000 1.25
NAcc intron excision ratio 0 0.000 1.21
NAcc mRNA stability 0 0.000 1.16
NAcc2 alternative polyA 0 0.000 1.23
NAcc2 alternative TSS 0 0.000 1.20
NAcc2 gene expression 0 0.000 1.27
NAcc2 isoform ratio 0 0.000 1.24
NAcc2 intron excision ratio 0 0.000 1.25
NAcc2 mRNA stability 0 0.000 1.26
OFC alternative polyA 0 0.000 1.11
OFC alternative TSS 0 0.000 1.14
OFC gene expression 0 0.000 1.25
OFC isoform ratio 0 0.000 1.07
OFC intron excision ratio 0 0.000 1.09
OFC mRNA stability 0 0.000 1.24
PL alternative polyA 0 0.000 1.19
PL alternative TSS 0 0.000 1.21
PL gene expression 0 0.000 1.26
PL isoform ratio 0 0.000 1.22
PL intron excision ratio 0 0.000 1.09
PL mRNA stability 0 0.000 1.21
PL2 alternative polyA 0 0.000 1.19
PL2 alternative TSS 0 0.000 1.19
PL2 gene expression 0 0.000 1.25
PL2 isoform ratio 0 0.000 1.10
PL2 intron excision ratio 0 0.000 1.22
PL2 mRNA stability 0 0.000 1.24

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.