Hub : Traits

light_reinforcement_lr_relactive

Light reinforcement, proportion of active snout-poke responses for 5-sec light onset to the total active and inactive responses in the last three 18-minute sessions during the light reinforcement phase for males and females [proportion]

Project: p50_david_dietz

15 significantly associated models · 4 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 9.6e-08 5.7e-02 6.5e-10 -954 Syt5
2 1 140614300 142727457 2 1 3.3e-09 1.2e-09 7.5e-02 91 Ctsc
3 5 58534361 59934060 1 1 7.6e-08 2.1e-04 1.3e-06 -70 Grhpr

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
body_g 2.6 1 0 0 0.00 1.0e+00 Syt5
dissection: PC 3 of all traits 4.2 1 0 0 0.00 1.0e+00 Grhpr
glucose_mg_dl 12.1 1 0 0 0.00 1.0e+00 Syt5
os_mean 10.7 2 0 0 -0.99 7.8e-08 Grm5 Ctsc
Tibia length in mm 7.5 1 0 0 0.00 1.0e+00 Syt5
Average time between licks in bursts 7.5 1 0 0 1.00 3.6e-10 Ctsc
Std. dev. time between licks in bursts 22.8 1 1 33 0.00 1.0e+00 Syt5
Average drop size 12.2 1 0 0 0.00 1.0e+00 Syt5
light_reinforcement_lr_active 11.3 4 1 33 0.99 7.9e-13 Grhpr Grm5 Ctsc Syt5
Delay discounting water rate 0 sec 8.8 2 0 0 0.00 1.0e+00 Grm5 Syt5
Median of all reaction times 7.0 1 0 0 0.00 1.0e+00 Syt5
locomotor_testing_activity 5.7 2 0 0 0.00 1.0e+00 Grm5 Ctsc
delay_discounting_pc1800 7.2 1 0 0 0.00 1.0e+00 Grhpr
reaction_time_falsealarm 11.8 2 0 0 0.99 3.4e-12 Grm5 Ctsc
social_reinforcement_socialrfq 8.0 1 0 0 0.00 1.0e+00 Syt5
reaction_time_pinit_slope 9.7 1 0 0 0.00 1.0e+00 Syt5
reaction_time_peropfalsealarm_slope 11.6 1 0 0 0.00 1.0e+00 Syt5
reaction_time_meanrt_slope 15.7 1 0 0 0.00 1.0e+00 Syt5
reaction_time_devmedrt_slope 42.2 1 1 33 0.00 1.0e+00 Syt5
ccp_trial_3_saline_dist_mm 23.3 1 1 33 0.00 1.0e+00 Syt5
Conditioned locomotion 15.1 1 0 0 0.00 1.0e+00 Syt5
Velocity during novelty place preference test 39.5 2 2 67 1.00 6.8e-18 Grm5 Ctsc
Trabecular tissue density 8.2 1 0 0 0.00 1.0e+00 Syt5
ctth_sd 7.8 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_mpc18 7.6 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc15 11.6 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc9 24.1 1 1 33 0.00 1.0e+00 Syt5
tautz: manual_mpc3 8.8 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc12 20.2 1 1 33 0.00 1.0e+00 Syt5
tautz: manual_spc14 8.9 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc8 7.5 2 0 0 -1.00 1.6e-04 Grm5 Ctsc
tautz: manual_mpc4 23.9 1 1 33 0.00 1.0e+00 Syt5
tautz: manual_mpc10 7.8 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_mpc5 23.6 1 1 33 0.00 1.0e+00 Syt5
tautz: manual_spc22 69.7 1 1 33 0.00 1.0e+00 Syt5
tautz: manual_mpc12 12.5 2 1 33 0.00 1.0e+00 Ctsc Syt5
tautz: manual_spc24 8.0 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc13 5.7 1 0 0 0.00 1.0e+00 Ctsc
tautz: manual_mpc19 32.6 1 1 33 0.00 1.0e+00 Syt5
tautz: manual_spc10 19.2 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc23 10.7 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc6 49.4 1 1 33 0.00 1.0e+00 Syt5
tautz: manual_mpc2 22.5 1 0 0 0.00 1.0e+00 Grhpr
tautz: manual_spc1 10.7 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_mpc13 8.8 2 0 0 -0.99 9.4e-06 Grm5 Ctsc
tautz: manual_spc5 17.8 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_spc3 11.2 1 0 0 0.00 1.0e+00 Syt5
tautz: manual_mpc6 7.4 2 0 0 1.00 5.2e-04 Grm5 Ctsc
tautz: manual_spc19 11.8 1 0 0 0.00 1.0e+00 Syt5
Ambulatory time at time1 of open field 36.6 1 1 33 0.00 1.0e+00 Syt5
The total number of resting periods in time1 37.4 1 1 33 0.00 1.0e+00 Syt5
punishment 133.8 1 1 33 0.00 1.0e+00 Syt5
runstartmale1 9.8 1 0 0 0.00 1.0e+00 Grm5
Weight adjusted by age 8.2 1 0 0 0.00 1.0e+00 Syt5
Liver cobalt concentration 19.4 1 0 0 0.00 1.0e+00 Syt5
Liver cadmium concentration 8.2 1 0 0 1.00 1.2e-07 Ctsc
Liver zinc concentration 15.8 2 0 0 0.00 1.0e+00 Grhpr Syt5
Liver sodium concentration 9.4 1 0 0 -1.00 6.2e-05 Ctsc

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.3
Adipose gene expression 0 0.000 1.3
Adipose isoform ratio 2 0.071 1.3
Adipose intron excision ratio 2 0.069 1.3
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 0 0.000 1.2
BLA alternative TSS 0 0.000 1.2
BLA gene expression 0 0.000 1.3
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.3
BLA mRNA stability 2 0.099 1.4
Brain alternative polyA 0 0.000 1.3
Brain alternative TSS 0 0.000 1.2
Brain gene expression 1 0.011 1.3
Brain isoform ratio 1 0.032 1.3
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.4
Eye alternative TSS 0 0.000 1.2
Eye gene expression 1 0.089 1.2
Eye isoform ratio 0 0.000 1.4
Eye intron excision ratio 0 0.000 1.3
Eye mRNA stability 0 0.000 1.5
IL alternative polyA 0 0.000 1.2
IL alternative TSS 0 0.000 1.2
IL gene expression 1 0.027 1.3
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.2
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.2
LHb alternative TSS 0 0.000 1.4
LHb gene expression 0 0.000 1.3
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 0 0.000 1.4
LHb mRNA stability 0 0.000 1.5
Liver alternative polyA 0 0.000 1.2
Liver alternative TSS 0 0.000 1.2
Liver gene expression 0 0.000 1.3
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 1 0.041 1.3
NAcc alternative polyA 0 0.000 1.3
NAcc alternative TSS 0 0.000 1.4
NAcc gene expression 1 0.030 1.3
NAcc isoform ratio 0 0.000 1.3
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 1 0.092 1.5
NAcc2 alternative polyA 0 0.000 1.3
NAcc2 alternative TSS 0 0.000 1.3
NAcc2 gene expression 1 0.019 1.3
NAcc2 isoform ratio 0 0.000 1.3
NAcc2 intron excision ratio 0 0.000 1.4
NAcc2 mRNA stability 0 0.000 1.4
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.3
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.3
PL alternative polyA 0 0.000 1.3
PL alternative TSS 0 0.000 1.2
PL gene expression 0 0.000 1.4
PL isoform ratio 0 0.000 1.4
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 1 0.087 1.5
PL2 alternative polyA 0 0.000 1.3
PL2 alternative TSS 0 0.000 1.3
PL2 gene expression 0 0.000 1.3
PL2 isoform ratio 0 0.000 1.3
PL2 intron excision ratio 0 0.000 1.4
PL2 mRNA stability 0 0.000 1.4

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.