Hub : Traits

Vertical activity count, locomotor time 2

Number of times vertical sensor beam was broken with each rearing bout separated by a period of not rearing (vertical sensor not activated) lasting 1s or longer in time2

Tags: Behavior · Locomotion

Project: u01_suzanne_mitchell

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	29741220	30154169	1	1	3.41e-07	1.06e-02	9.62e-02	Slc12a7

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Light reinforcement 1	2.61	1	0	0	0	1e+00	Slc12a7
Reaction time mean minus median	6.36	1	0	0	0	1e+00	Slc12a7
Reaction time mean minus median AUC	6.79	1	0	0	0	1e+00	Slc12a7
Std. dev. reaction times	5.82	1	0	0	0	1e+00	Slc12a7
Social response proportion	3.91	1	0	0	0	1e+00	Slc12a7
Conditioned reinforcement - actives	5.13	1	0	0	0	1e+00	Slc12a7
Conditioned locomotion	3.58	1	0	0	0	1e+00	Slc12a7
Intermittent access day 1 total infusions	4.5	1	0	0	0	1e+00	Slc12a7
Intermittent access terminal intake (last 3 days)	3.77	1	0	0	0	1e+00	Slc12a7
Intermittent access total infusions	4.49	1	0	0	0	1e+00	Slc12a7
Intermittent access day 15 total locomotion	4.65	1	0	0	0	1e+00	Slc12a7
Lifetime Intake	5.74	1	0	0	0	1e+00	Slc12a7
Progressive ratio test 1 active lever presses	8.52	1	0	0	0	1e+00	Slc12a7
Progressive ratio test 1 breakpoint	9.59	1	0	0	0	1e+00	Slc12a7
Total sessions with >9 infusions	4.15	1	0	0	0	1e+00	Slc12a7
Short access day 10 total infusions	5.86	1	0	0	0	1e+00	Slc12a7
Short access total infusions	6.06	1	0	0	0	1e+00	Slc12a7
Total zone transitions, hab. session 2	3.74	1	0	0	0	1e+00	Slc12a7
Distance traveled after self-admin	7.34	1	0	0	0	1e+00	Slc12a7
Extinction: sum of active levers before priming	8.15	1	0	0	0	1e+00	Slc12a7
Delta distance traveled before/after self-admin	4.95	1	0	0	0	1e+00	Slc12a7
Delta ambulatory time before/after self-admin	5.8	1	0	0	0	1e+00	Slc12a7
Delta time to tail flick, vehicle, before/after SA	4.85	1	0	0	0	1e+00	Slc12a7
Ambulatory time after self-admin	6.39	1	0	0	0	1e+00	Slc12a7
Delay disc. indifference point, 0s delay	4.12	1	0	0	0	1e+00	Slc12a7
Delay disc. indifference point, 8s delay	5.96	1	0	0	0	1e+00	Slc12a7
Time >=10cm from walls, locomotor time 1	15.39	1	0	0	0	1e+00	Slc12a7
Rest time, locomotor task time 1	13.45	1	0	0	0	1e+00	Slc12a7
Distance moved, locomotor task time 1	3.55	1	0	0	0	1e+00	Slc12a7
Vertical activity count, locomotor time 1	7.92	1	0	0	0	1e+00	Slc12a7
Time >=10cm from walls, locomotor time 2	11.53	1	0	0	0	1e+00	Slc12a7
Bouts of movement, locomotor time 2	3.87	1	0	0	0	1e+00	Slc12a7
Total resting periods, locomotor time 2	4.06	1	0	0	0	1e+00	Slc12a7
Rest time, locomotor task time 2	14.04	1	0	0	0	1e+00	Slc12a7
Distance moved, locomotor task time 2	3.9	1	0	0	0	1e+00	Slc12a7
Locomotion in novel chamber post-restriction	7.07	1	0	0	0	1e+00	Slc12a7
Run reversals in cocaine runway, females	4.09	1	0	0	0	1e+00	Slc12a7

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.99
Adipose	alternative TSS	0	0	1.1
Adipose	gene expression	0	0	1.07
Adipose	isoform ratio	0	0	1.1
Adipose	intron excision ratio	0	0	1.19
Adipose	mRNA stability	0	0	1.06
BLA	alternative polyA	0	0	1.16
BLA	alternative TSS	0	0	1.21
BLA	gene expression	0	0	1.11
BLA	isoform ratio	0	0	1.09
BLA	intron excision ratio	0	0	1.15
BLA	mRNA stability	0	0	1.13
Brain	alternative polyA	0	0	1.04
Brain	alternative TSS	1	0.1	1.2
Brain	gene expression	0	0	1.1
Brain	isoform ratio	0	0	1.04
Brain	intron excision ratio	0	0	1.1
Brain	mRNA stability	0	0	1.09
Eye	alternative polyA	0	0	1
Eye	alternative TSS	0	0	0.99
Eye	gene expression	0	0	1.02
Eye	isoform ratio	0	0	1.26
Eye	intron excision ratio	0	0	1.07
Eye	mRNA stability	0	0	1.25
IL	alternative polyA	0	0	1.09
IL	alternative TSS	0	0	1.32
IL	gene expression	0	0	1.11
IL	isoform ratio	0	0	1.23
IL	intron excision ratio	0	0	1.11
IL	mRNA stability	0	0	1.13
LHb	alternative polyA	0	0	0.96
LHb	alternative TSS	0	0	1.13
LHb	gene expression	0	0	1.13
LHb	isoform ratio	0	0	1.17
LHb	intron excision ratio	0	0	1.13
LHb	mRNA stability	0	0	1.14
Liver	alternative polyA	0	0	1.08
Liver	alternative TSS	0	0	1.03
Liver	gene expression	0	0	1.07
Liver	isoform ratio	0	0	1.07
Liver	intron excision ratio	0	0	1.12
Liver	mRNA stability	0	0	1.08
NAcc	alternative polyA	0	0	0.99
NAcc	alternative TSS	0	0	1.21
NAcc	gene expression	0	0	1.11
NAcc	isoform ratio	0	0	1.07
NAcc	intron excision ratio	0	0	1.09
NAcc	mRNA stability	0	0	1.12
OFC	alternative polyA	0	0	1.04
OFC	alternative TSS	0	0	1.16
OFC	gene expression	0	0	1.13
OFC	isoform ratio	0	0	1.18
OFC	intron excision ratio	0	0	1.17
OFC	mRNA stability	0	0	1.11
PL	alternative polyA	0	0	1.07
PL	alternative TSS	0	0	1.19
PL	gene expression	0	0	1.1
PL	isoform ratio	0	0	1.05
PL	intron excision ratio	0	0	1.06
PL	mRNA stability	0	0	1.13