Hub : Traits

Locomotor testing distance

Distance traveled in a novel 24 X 45 cm chamber in the 18-minute session for males and females [cm],locomotor_testing_distance

Tags: Behavior · Locomotion

Project: p50_david_dietz

2 loci · 2 genes with independent associations · 4 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	6	60576851	62029190	2	1	2.35e-07	1.29e-07	2.17e-81	Pnpla8
2	10	25764403	27626792	2	1	8.77e-08	5.22e-08	1.00e+00	Gabrg2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Length with tail	3.45	4	0	0	-0.53	2.77e-01	Gabrg2 Gabrb2 Pnpla8 ENSRNOG00000068595
Length without tail	4.89	3	0	0	-0.86	6.47e-02	Gabrg2 Pnpla8 ENSRNOG00000068595
Tibialis anterior weight	2.67	2	0	0	0	1.00e+00	Pnpla8 ENSRNOG00000068595
Times rat made contact with spout	6.65	2	0	0	0	1.00e+00	Pnpla8 ENSRNOG00000068595
Delay discounting time to switch 0 sec	7.7	2	0	0	0	1.00e+00	Pnpla8 ENSRNOG00000068595
Locomotor activity	11.5	4	2	100	-0.58	2.24e-01	Gabrg2 Gabrb2 Pnpla8 ENSRNOG00000068595
Locomotor testing rearing	12.62	4	0	0	0.83	4.10e-02	Gabrg2 Gabrb2 Pnpla8 ENSRNOG00000068595
Reaction time number correct	11.51	2	0	0	0.66	3.36e-01	Gabrg2 Gabrb2
Reaction time mean minus median	6.49	2	0	0	-0.5	5.04e-01	Gabrg2 Gabrb2
Reaction time trials correct on left	11.51	2	0	0	0.66	3.36e-01	Gabrg2 Gabrb2
Reaction time trials on left	11.74	2	0	0	0.66	3.42e-01	Gabrg2 Gabrb2
Reaction time mean	8.67	2	0	0	-0.09	9.14e-01	Gabrg2 Gabrb2
Reaction time mean AUC	8.45	2	0	0	0.01	9.95e-01	Gabrg2 Gabrb2
Median of all reaction times	6.81	2	0	0	0.23	7.68e-01	Gabrg2 Gabrb2
Std. dev. reaction times	5.47	1	0	0	0	1.00e+00	Gabrg2
Reaction time trials completed	11.74	2	0	0	0.66	3.42e-01	Gabrg2 Gabrb2
Reaction time trials AUC	12.32	2	0	0	0.59	4.08e-01	Gabrg2 Gabrb2
Conditioned locomotion	9.1	2	0	0	0	1.00e+00	Pnpla8 ENSRNOG00000068595
Condit. Reinf. active responses	5.06	1	0	0	0	1.00e+00	Gabrg2
Condit. Reinf. lever reinforcers received	5.25	2	0	0	-0.36	6.38e-01	Gabrg2 Gabrb2
Bone: cortical area	4.8	1	0	0	0	1.00e+00	Gabrb2
Bone: cortical thickness	4.95	1	0	0	0	1.00e+00	Gabrb2
Run reversals in cocaine runway, females	7.62	2	0	0	0	1.00e+00	Pnpla8 ENSRNOG00000068595
Cd content in liver	10.76	2	0	0	-0.35	6.49e-01	Gabrg2 Gabrb2
Co content in liver	7.25	2	0	0	0	1.00e+00	Pnpla8 ENSRNOG00000068595

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.67
Adipose	alternative TSS	0	0	1.58
Adipose	gene expression	1	0	1.61
Adipose	isoform ratio	0	0	1.68
Adipose	intron excision ratio	0	0	1.65
Adipose	mRNA stability	0	0	1.68
BLA	alternative polyA	0	0	1.62
BLA	alternative TSS	0	0	1.74
BLA	gene expression	1	0	1.72
BLA	isoform ratio	0	0	1.66
BLA	intron excision ratio	0	0	1.72
BLA	mRNA stability	0	0	1.8
Brain	alternative polyA	0	0	1.61
Brain	alternative TSS	0	0	1.58
Brain	gene expression	0	0	1.67
Brain	isoform ratio	0	0	1.69
Brain	intron excision ratio	0	0	1.67
Brain	mRNA stability	1	0	1.66
Eye	alternative polyA	0	0	1.94
Eye	alternative TSS	0	0	1.47
Eye	gene expression	0	0	1.73
Eye	isoform ratio	0	0	1.64
Eye	intron excision ratio	0	0	1.78
Eye	mRNA stability	0	0	1.6
IL	alternative polyA	0	0	1.6
IL	alternative TSS	0	0	2.02
IL	gene expression	0	0	1.67
IL	isoform ratio	0	0	1.52
IL	intron excision ratio	0	0	1.77
IL	mRNA stability	1	0.1	1.83
LHb	alternative polyA	0	0	1.45
LHb	alternative TSS	0	0	1.66
LHb	gene expression	0	0	1.65
LHb	isoform ratio	0	0	1.78
LHb	intron excision ratio	0	0	1.73
LHb	mRNA stability	0	0	1.72
Liver	alternative polyA	0	0	1.65
Liver	alternative TSS	0	0	1.47
Liver	gene expression	0	0	1.62
Liver	isoform ratio	0	0	1.63
Liver	intron excision ratio	0	0	1.55
Liver	mRNA stability	0	0	1.58
NAcc	alternative polyA	0	0	1.59
NAcc	alternative TSS	0	0	1.67
NAcc	gene expression	0	0	1.68
NAcc	isoform ratio	0	0	1.66
NAcc	intron excision ratio	0	0	1.65
NAcc	mRNA stability	1	0	1.7
OFC	alternative polyA	0	0	1.52
OFC	alternative TSS	0	0	1.9
OFC	gene expression	1	0	1.66
OFC	isoform ratio	0	0	1.6
OFC	intron excision ratio	0	0	1.86
OFC	mRNA stability	0	0	1.8
PL	alternative polyA	0	0	1.55
PL	alternative TSS	0	0	1.77
PL	gene expression	0	0	1.69
PL	isoform ratio	0	0	1.7
PL	intron excision ratio	0	0	1.61
PL	mRNA stability	0	0	1.67