Hub : Traits

Post-drug Anxiety

Post-drug hide time

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	2	90636696	92031287	1	1	2.45e-09	2.71e-02	1.75e-10	Snx16

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.94	1	0	0	0	1e+00	Snx16
BMI without tail	22.63	1	1	100	0	1e+00	Snx16
Body weight	5	1	0	0	0	1e+00	Snx16
Epididymis fat weight	1.95	1	0	0	0	1e+00	Snx16
Heart weight	3.09	1	0	0	0	1e+00	Snx16
Tail length	14.44	1	1	100	0	1e+00	Snx16
Length with tail	2.62	1	0	0	0	1e+00	Snx16
Length without tail	2.77	1	0	0	0	1e+00	Snx16
Liver weight, right	3.45	1	0	0	0	1e+00	Snx16
Intraocular pressure	5.47	1	0	0	0	1e+00	Snx16
Extensor digitorum longus weight	8.22	1	1	100	0	1e+00	Snx16
Tibialis anterior weight	8.13	1	1	100	0	1e+00	Snx16
Mean time between licks in bursts	3.01	1	0	0	0	1e+00	Snx16
Indifference point AUC	16.61	1	0	0	0	1e+00	Snx16
Indifference point function ln k	3.46	1	0	0	0	1e+00	Snx16
Indifference point function log k	3.46	1	0	0	0	1e+00	Snx16
Delay discounting total patch changes 12 sec	3.69	1	0	0	0	1e+00	Snx16
Delay discounting total patch changes 18 sec	4.84	1	0	0	0	1e+00	Snx16
Delay discounting total patch changes 6 sec	4.26	1	0	0	0	1e+00	Snx16
Delay discounting time to switch 0 sec	11.43	1	0	0	0	1e+00	Snx16
Delay discounting water rate 0 sec	3.59	1	0	0	0	1e+00	Snx16
Delay discounting water rate 6 sec	3.08	1	0	0	0	1e+00	Snx16
Locomotor activity	2.5	1	0	0	0	1e+00	Snx16
Reaction time number correct	5.61	1	0	0	0	1e+00	Snx16
Reaction time mean minus median	5.82	1	0	0	0	1e+00	Snx16
Reaction time mean minus median AUC	6.13	1	0	0	0	1e+00	Snx16
Reaction time num false alarms	7.69	1	0	0	0	1e+00	Snx16
Reaction time trials correct on left	5.61	1	0	0	0	1e+00	Snx16
Reaction time trials on left	5.27	1	0	0	0	1e+00	Snx16
Reaction time omissions	7.27	1	0	0	0	1e+00	Snx16
Std. dev. reaction times	7.62	1	0	0	0	1e+00	Snx16
Reaction time trials completed	5.27	1	0	0	0	1e+00	Snx16
Reaction time trials AUC	6.19	1	0	0	0	1e+00	Snx16
Social responses	8.27	1	0	0	0	1e+00	Snx16
Intermittent access intake day 1-15 change	14.53	1	0	0	0	1e+00	Snx16
Intermittent access intake escalation	12.85	1	0	0	0	1e+00	Snx16
Intermittent access intake escalation 2	28.12	1	1	100	0	1e+00	Snx16
Intermittent access terminal intake (last 3 days)	6.27	1	0	0	0	1e+00	Snx16
Intermittent access standard deviation	19.77	1	0	0	0	1e+00	Snx16
Cocaine induced anxiety	13.98	1	0	0	0	1e+00	Snx16
Progressive ratio test 1 active lever presses	8	1	0	0	0	1e+00	Snx16
Progressive ratio test 1 breakpoint	4.3	1	0	0	0	1e+00	Snx16
Progressive ratio test 1 inactive lever presses	3.9	1	0	0	0	1e+00	Snx16
Short access day 10 total locomotion	3.77	1	0	0	0	1e+00	Snx16
One hour access (shock baseline)	3.82	1	0	0	0	1e+00	Snx16
Stereotopy head waving bouts, day 7	4.53	1	0	0	0	1e+00	Snx16
Stereotopy head waving duration, day 7	4.22	1	0	0	0	1e+00	Snx16
Degree of sensitization stereotypy	4.37	1	0	0	0	1e+00	Snx16
Condit. Reinf. active-inactive response ratio	4.91	1	0	0	0	1e+00	Snx16
Time in familiar zone, hab. session 1	12.34	1	0	0	0	1e+00	Snx16
Time in novel zone, hab. session 1	6.17	1	0	0	0	1e+00	Snx16
Time in familiar zone, hab. session 2	6.08	1	0	0	0	1e+00	Snx16
Bone: elastic displacement	4.4	1	0	0	0	1e+00	Snx16
Bone: elastic work	4.59	1	0	0	0	1e+00	Snx16
Bone: endosteal estimation	3.81	1	0	0	0	1e+00	Snx16
Bone: final force	3.6	1	0	0	0	1e+00	Snx16
Bone: final moment	3.33	1	0	0	0	1e+00	Snx16
Bone: marrow area	4.3	1	0	0	0	1e+00	Snx16
Bone: maximum force	2.93	1	0	0	0	1e+00	Snx16
Bone: maximum moment	2.58	1	0	0	0	1e+00	Snx16
Bone: minimum diameter	7.56	1	0	0	0	1e+00	Snx16
Bone: periosteal estimation	4.43	1	0	0	0	1e+00	Snx16
Bone: trabecular number	2.84	1	0	0	0	1e+00	Snx16
Distance traveled before self-admin	16.96	1	0	0	0	1e+00	Snx16
Distance traveled after self-admin	7.3	1	0	0	0	1e+00	Snx16
Delta time in closed arm before/after self-admin	8.57	1	0	0	0	1e+00	Snx16
Diff in mean of infusions in LGA sessions	9.81	1	0	0	0	1e+00	Snx16
Active lever presses in extinction session 6	8.37	1	0	0	0	1e+00	Snx16
Time in closed arm after self-admin	4.03	1	0	0	0	1e+00	Snx16
Time in open arm before self-admin	5.63	1	0	0	0	1e+00	Snx16
Time to tail flick, vehicle, before self-admin	9.86	1	0	0	0	1e+00	Snx16
Time to tail flick, test, before self-admin	20.61	1	0	0	0	1e+00	Snx16
Ambulatory time after self-admin	5.2	1	0	0	0	1e+00	Snx16
Delay disc. indifference point, 8s delay	8.92	1	0	0	0	1e+00	Snx16
Fecal boli incidents, locomotor time 1	7.47	1	0	0	0	1e+00	Snx16
Time >=10cm from walls, locomotor time 1	13.93	1	0	0	0	1e+00	Snx16
Bouts of movement, locomotor time 1	10.54	1	0	0	0	1e+00	Snx16
Total resting periods, locomotor time 1	4.63	1	0	0	0	1e+00	Snx16
Total resting periods, locomotor time 2	4.79	1	0	0	0	1e+00	Snx16
Rest time, locomotor task time 2	5.23	1	0	0	0	1e+00	Snx16
Weight adjusted by age	50.32	1	1	100	0	1e+00	Snx16
Seeking ratio, delayed vs. immediate footshock	22.65	1	1	100	0	1e+00	Snx16
Locomotion in novel chamber post-restriction	3.49	1	0	0	0	1e+00	Snx16
Food seeking constrained by brief footshock	16.73	1	0	0	0	1e+00	Snx16
Latency to leave start box in cocaine runway, F	4.25	1	0	0	0	1e+00	Snx16
Na content in liver	3.69	1	0	0	0	1e+00	Snx16

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.05
Adipose	alternative TSS	0	0	1.23
Adipose	gene expression	1	0	1.13
Adipose	isoform ratio	0	0	1.11
Adipose	intron excision ratio	0	0	1.11
Adipose	mRNA stability	0	0	1.05
BLA	alternative polyA	0	0	1.06
BLA	alternative TSS	0	0	1.1
BLA	gene expression	0	0	1.1
BLA	isoform ratio	0	0	1.17
BLA	intron excision ratio	0	0	1.13
BLA	mRNA stability	0	0	1.14
Brain	alternative polyA	0	0	1.13
Brain	alternative TSS	0	0	1.14
Brain	gene expression	0	0	1.09
Brain	isoform ratio	0	0	1.13
Brain	intron excision ratio	0	0	1.12
Brain	mRNA stability	0	0	1.09
Eye	alternative polyA	0	0	1.56
Eye	alternative TSS	0	0	1.2
Eye	gene expression	0	0	1.14
Eye	isoform ratio	0	0	1.15
Eye	intron excision ratio	0	0	1.11
Eye	mRNA stability	0	0	1.16
IL	alternative polyA	0	0	1.16
IL	alternative TSS	0	0	1.28
IL	gene expression	0	0	1.07
IL	isoform ratio	0	0	1.18
IL	intron excision ratio	0	0	1.03
IL	mRNA stability	0	0	1.06
LHb	alternative polyA	0	0	1.11
LHb	alternative TSS	0	0	0.96
LHb	gene expression	0	0	1.1
LHb	isoform ratio	0	0	1.1
LHb	intron excision ratio	0	0	1.09
LHb	mRNA stability	0	0	1.03
Liver	alternative polyA	0	0	1.12
Liver	alternative TSS	0	0	1.11
Liver	gene expression	0	0	1.11
Liver	isoform ratio	0	0	1.14
Liver	intron excision ratio	0	0	1.09
Liver	mRNA stability	0	0	1.1
NAcc	alternative polyA	0	0	1.1
NAcc	alternative TSS	0	0	1.15
NAcc	gene expression	0	0	1.07
NAcc	isoform ratio	0	0	1.2
NAcc	intron excision ratio	0	0	1.15
NAcc	mRNA stability	0	0	1.1
OFC	alternative polyA	0	0	1.08
OFC	alternative TSS	0	0	1.15
OFC	gene expression	0	0	1.07
OFC	isoform ratio	0	0	1.12
OFC	intron excision ratio	0	0	1.06
OFC	mRNA stability	0	0	1.08
PL	alternative polyA	0	0	1.1
PL	alternative TSS	0	0	1.19
PL	gene expression	0	0	1.1
PL	isoform ratio	0	0	1.16
PL	intron excision ratio	0	0	1.12
PL	mRNA stability	0	0	1.1