Hub : Traits

Cocaine induced anxiety

Post-drug hide time minus pre-drug hide time

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	10	46789397	48185455	1	1	1.59e-09	6.70e-01	1.00e+00	Trim16
2	15	24291347	25661910	1	1	1.88e-08	3.08e-02	4.87e-07	Rab2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	1.44	1	0	0	0	1e+00	Rab2b
Heart weight	7.82	1	0	0	0	1e+00	Trim16
Liver weight, left	7.8	1	0	0	0	1e+00	Trim16
Parametrial fat weight	3.02	1	0	0	0	1e+00	Rab2b
Intraocular pressure	38.81	1	1	50	0	1e+00	Trim16
Extensor digitorum longus weight	2.27	1	0	0	0	1e+00	Rab2b
Tibialis anterior weight	1.88	1	0	0	0	1e+00	Rab2b
Number of licking bursts	19.25	1	0	0	0	1e+00	Trim16
Food consumed during 24 hour testing period	10.07	2	0	0	0	1e+00	Trim16 Rab2b
Times rat made contact with spout	16.5	1	0	0	0	1e+00	Trim16
Mean time between licks in bursts	5.09	1	0	0	0	1e+00	Rab2b
Mean num. licks in bursts	46	1	1	50	0	1e+00	Trim16
Std. dev. time between licks in bursts	5.37	1	0	0	0	1e+00	Trim16
Water consumed over 24 hours	23.78	1	1	50	0	1e+00	Trim16
Indifference point 0 sec	7.93	1	0	0	0	1e+00	Trim16
Delay discounting total patch changes 0 sec	8.46	1	0	0	0	1e+00	Trim16
Delay discounting total patch changes 18 sec	45.74	1	1	50	0	1e+00	Trim16
Delay discounting total patch changes 24 sec	5.62	1	0	0	0	1e+00	Rab2b
Delay discounting total patch changes 6 sec	5.01	1	0	0	0	1e+00	Trim16
Delay discounting water rate 0 sec	15.05	1	0	0	0	1e+00	Trim16
Delay discounting water rate 6 sec	7.21	1	0	0	0	1e+00	Trim16
Locomotor activity	4.93	1	0	0	0	1e+00	Trim16
Light reinforcement 1	3.9	1	0	0	0	1e+00	Rab2b
Reaction time number correct	7.52	1	0	0	0	1e+00	Trim16
Reaction time trials correct on left	7.52	1	0	0	0	1e+00	Trim16
Reaction time trials on left	6.91	1	0	0	0	1e+00	Trim16
Reaction time premature initiation rate	5.84	1	0	0	0	1e+00	Trim16
Reaction time trials completed	6.91	1	0	0	0	1e+00	Trim16
Reaction time trials AUC	5.96	1	0	0	0	1e+00	Trim16
Social time	25.91	1	1	50	0	1e+00	Trim16
Cocaine response after cond. corrected	14.58	1	0	0	0	1e+00	Trim16
Cocaine response after cond. not corrected	16	1	0	0	0	1e+00	Trim16
Condit. Reinf. lever presses	7.41	1	0	0	0	1e+00	Trim16
Pavlov. Cond. intertrial magazine entries	4.81	1	0	0	0	1e+00	Rab2b
Intermitt. access day 1 inactive lever presses	36.63	1	1	50	0	1e+00	Trim16
Intermitt. access escalation Index	27.6	1	0	0	0	1e+00	Trim16
Intermittent access day 15 total infusions	7.78	1	0	0	0	1e+00	Rab2b
Intermittent access total infusions	8.75	1	0	0	0	1e+00	Rab2b
Intermittent access day 1 locomotion	12.82	1	0	0	0	1e+00	Trim16
Intermittent access total locomotion	7.7	2	0	0	0	1e+00	Trim16 Rab2b
Intermittent access standard deviation	13.26	1	0	0	0	1e+00	Rab2b
Post-drug Anxiety	16.04	2	0	0	0	1e+00	Trim16 Rab2b
Baseline Anxiety	15	2	1	50	0	1e+00	Trim16 Rab2b
Lifetime Intake	14.32	1	0	0	0	1e+00	Rab2b
Progressive ratio test 1 inactive lever presses	18.46	2	1	50	0	1e+00	Trim16 Rab2b
Progressive ratio test 2 active lever presses	6.19	1	0	0	0	1e+00	Rab2b
Progressive ratio test 2 breakpoint	5.82	1	0	0	0	1e+00	Rab2b
Progressive ratio test 2 inactive lever presses	5.96	1	0	0	0	1e+00	Rab2b
Total sessions with >9 infusions	13.7	1	0	0	0	1e+00	Trim16
Short access day 1 total inactive lever presses	13.77	1	0	0	0	1e+00	Trim16
Short access day 10 total inactive lever presses	12.36	1	0	0	0	1e+00	Rab2b
Short access day 1 total infusions	28.86	2	1	50	0	1e+00	Trim16 Rab2b
Short access total infusions	10.18	1	0	0	0	1e+00	Rab2b
Short access day 1 locomotion	33.14	1	1	50	0	1e+00	Trim16
Short access day 10 total locomotion	14.27	1	0	0	0	1e+00	Trim16
Short access total locomotion	7.84	2	0	0	0	1e+00	Trim16 Rab2b
Compulsive drug intake	11.93	1	0	0	0	1e+00	Trim16
One hour access (0.3 mA shock)	7.8	1	0	0	0	1e+00	Rab2b
One hour access (shock baseline)	16.38	1	0	0	0	1e+00	Rab2b
Number of responses in last shaping day	16.26	2	1	50	0	1e+00	Trim16 Rab2b
Context. condit. distance diff. score	5	1	0	0	0	1e+00	Trim16
Locomotion distance, session 1	31.9	1	1	50	0	1e+00	Trim16
Locomotion distance, session 2	15.7	1	0	0	0	1e+00	Trim16
Stereotopy head waving bouts, day 7	25.38	1	1	50	0	1e+00	Trim16
Stereotopy head waving duration, day 7	6.53	1	0	0	0	1e+00	Trim16
Degree of sensitization stereotypy	7.41	1	0	0	0	1e+00	Trim16
Incentive salience index mean	5.91	1	0	0	0	1e+00	Trim16
Time in familiar zone, hab. session 1	6.6	1	0	0	0	1e+00	Trim16
Total zone transitions, hab. session 1	37.38	1	1	50	0	1e+00	Trim16
Total locomotion distance, hab. session 1	38.46	1	1	50	0	1e+00	Trim16
Locomotion velocity, hab. session 1	30.22	1	1	50	0	1e+00	Trim16
Time in familiar zone, hab. session 2	8.57	1	0	0	0	1e+00	Trim16
Total locomotion distance, hab. session 2	11.5	1	0	0	0	1e+00	Trim16
Locomotion velocity, hab. session 2	9.98	1	0	0	0	1e+00	Trim16
Total locomotion distance, NPP test	4.55	1	0	0	0	1e+00	Trim16
Pavlov. Cond. magazine entry latency	30.95	1	1	50	0	1e+00	Trim16
Pavlov. Cond. index score	10.8	1	0	0	0	1e+00	Trim16
Pavlov. Cond. latency score	5.87	1	0	0	0	1e+00	Trim16
Pavlov. Cond. magazine entry number	28.02	1	1	50	0	1e+00	Trim16
Pavlov. Cond. intertrial magazine entries	14.36	1	0	0	0	1e+00	Trim16
Pavlov. Cond. lever-magazine prob. diff.	10.24	1	0	0	0	1e+00	Trim16
Pavlov. Cond. response bias	8.26	1	0	0	0	1e+00	Trim16
Bone: cortical apparent density	18.12	1	0	0	0	1e+00	Trim16
Bone: cortical porosity	21.5	1	0	0	0	1e+00	Trim16
Bone: cortical porosity	27.37	1	1	50	0	1e+00	Trim16
Bone: cortical tissue density	19.62	1	0	0	0	1e+00	Trim16
Bone: elastic work	5.85	1	0	0	0	1e+00	Trim16
Bone: post-yield work	16.22	1	0	0	0	1e+00	Trim16
Bone: tissue strength	7.44	1	0	0	0	1e+00	Trim16
Distance traveled before self-admin	11.22	1	0	0	0	1e+00	Rab2b
Distance traveled after self-admin	6.93	1	0	0	0	1e+00	Rab2b
Time in closed arm after self-admin	8.67	1	0	0	0	1e+00	Rab2b
Time to tail flick, test, after self-admin	9.27	1	0	0	0	1e+00	Rab2b
Ambulatory time before self-admin	14.08	1	0	0	0	1e+00	Rab2b
Ambulatory time after self-admin	5.92	1	0	0	0	1e+00	Rab2b
Delay disc. indifference point, 16s delay	6.6	1	0	0	0	1e+00	Trim16
Delay disc. indifference point, 24s delay	11.46	1	0	0	0	1e+00	Rab2b
Time >=10cm from walls, locomotor time 1	13.65	1	0	0	0	1e+00	Rab2b
Bouts of movement, locomotor time 1	5.46	1	0	0	0	1e+00	Rab2b
Bouts of movement, locomotor time 2	6.79	1	0	0	0	1e+00	Rab2b
Total resting periods, locomotor time 2	5.87	1	0	0	0	1e+00	Rab2b
Distance moved, locomotor task time 2	6.59	1	0	0	0	1e+00	Trim16
Run reversals in cocaine runway, females	11.6	1	0	0	0	1e+00	Trim16
Run reversals in cocaine runway, males	6.16	1	0	0	0	1e+00	Trim16
Latency to leave start box in cocaine runway	10.82	2	0	0	0	1e+00	Trim16 Rab2b
Latency to leave start box in cocaine runway, F	7.35	1	0	0	0	1e+00	Trim16
Latency to leave start box in cocaine runway, M	6.37	1	0	0	0	1e+00	Rab2b
Cu content in liver	6.23	1	0	0	0	1e+00	Trim16
K content in liver	8.32	1	0	0	0	1e+00	Trim16
Mg content in liver	28.9	1	1	50	0	1e+00	Trim16
Rb content in liver	24.76	1	1	50	0	1e+00	Trim16
Se content in liver	19.76	1	0	0	0	1e+00	Trim16

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	2	0.1	1.26
Adipose	alternative TSS	0	0	1.13
Adipose	gene expression	0	0	1.12
Adipose	isoform ratio	0	0	1.17
Adipose	intron excision ratio	0	0	1.18
Adipose	mRNA stability	0	0	1.11
BLA	alternative polyA	0	0	1.07
BLA	alternative TSS	0	0	1.19
BLA	gene expression	0	0	1.11
BLA	isoform ratio	0	0	1.17
BLA	intron excision ratio	0	0	1.18
BLA	mRNA stability	0	0	1.16
Brain	alternative polyA	0	0	1.21
Brain	alternative TSS	0	0	1.18
Brain	gene expression	0	0	1.11
Brain	isoform ratio	0	0	1.2
Brain	intron excision ratio	0	0	1.17
Brain	mRNA stability	0	0	1.15
Eye	alternative polyA	0	0	1.29
Eye	alternative TSS	0	0	1.19
Eye	gene expression	0	0	1.1
Eye	isoform ratio	0	0	1.26
Eye	intron excision ratio	0	0	1.16
Eye	mRNA stability	0	0	1.25
IL	alternative polyA	0	0	1.07
IL	alternative TSS	0	0	1.35
IL	gene expression	0	0	1.13
IL	isoform ratio	0	0	1.27
IL	intron excision ratio	0	0	1.1
IL	mRNA stability	0	0	1.09
LHb	alternative polyA	0	0	1.14
LHb	alternative TSS	0	0	1.13
LHb	gene expression	0	0	1.19
LHb	isoform ratio	0	0	1.14
LHb	intron excision ratio	0	0	1.27
LHb	mRNA stability	0	0	1.2
Liver	alternative polyA	0	0	1.2
Liver	alternative TSS	0	0	1.21
Liver	gene expression	0	0	1.14
Liver	isoform ratio	0	0	1.17
Liver	intron excision ratio	0	0	1.19
Liver	mRNA stability	0	0	1.15
NAcc	alternative polyA	0	0	1.1
NAcc	alternative TSS	0	0	1.18
NAcc	gene expression	0	0	1.13
NAcc	isoform ratio	0	0	1.18
NAcc	intron excision ratio	0	0	1.24
NAcc	mRNA stability	0	0	1.17
OFC	alternative polyA	0	0	1
OFC	alternative TSS	0	0	1.21
OFC	gene expression	0	0	1.14
OFC	isoform ratio	0	0	1.08
OFC	intron excision ratio	0	0	1.19
OFC	mRNA stability	0	0	1.2
PL	alternative polyA	0	0	1.1
PL	alternative TSS	0	0	1.33
PL	gene expression	1	0	1.12
PL	isoform ratio	0	0	1.17
PL	intron excision ratio	0	0	1.2
PL	mRNA stability	0	0	1.15