Intermitt. access day 15 inactive lever presses

Intermittent access day 15 total inactive lever presses

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

3 loci · 5 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	7.12e-11	4.77e-03	1.89e-08	Syt5
2	6	24048319	25760913	3	3	3.87e-09	1.85e-04	1.00e+00	Rbks Supt7l AABR07063281.1
3	8	108584253	109479622	1	1	3.87e-08	3.34e-02	2.30e-03	Apeh

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
Body weight	2.17	2	0	0	0	1.00e+00	Rbks Syt5
Epididymis fat weight	7.63	2	0	0	0	1.00e+00	Rbks AABR07063281.1
Glucose	12.08	1	0	0	0	1.00e+00	Syt5
Heart weight	7.03	1	0	0	0	1.00e+00	Supt7l
Right kidney weight	2.68	3	0	0	0	1.00e+00	Rbks Syt5 AABR07063281.1
Length without tail	3.25	1	0	0	0	1.00e+00	Syt5
Liver weight, left	10.21	1	0	0	0	1.00e+00	Syt5
Liver weight, right	11.2	1	0	0	0	1.00e+00	Syt5
Retroperitoneal fat weight	5.83	2	1	20	0	1.00e+00	Rbks AABR07063281.1
Intraocular pressure	7.57	2	0	0	0	1.00e+00	Rbks AABR07063281.1
Extensor digitorum longus weight	2.16	1	0	0	0	1.00e+00	AABR07063281.1
Tibialis anterior weight	2.35	1	0	0	0	1.00e+00	Syt5
Tibia length	7.53	1	0	0	0	1.00e+00	Syt5
Std. dev. time between licks in bursts	14.8	2	1	20	0	1.00e+00	Syt5 Apeh
Indifference point 0 sec	6.32	1	0	0	0	1.00e+00	Syt5
Indifference point function ln k	8.79	1	0	0	0	1.00e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 0 sec	5.75	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 18 sec	5.91	1	0	0	0	1.00e+00	Apeh
Delay discounting total patch changes 24 sec	10.35	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 6 sec	4.88	1	0	0	0	1.00e+00	Apeh
Delay discounting time to switch 0 sec	55.89	1	1	20	0	1.00e+00	Syt5
Delay discounting water rate 0 sec	10.34	1	0	0	0	1.00e+00	Syt5
Delay discounting water rate 12 sec	22.12	1	1	20	0	1.00e+00	Syt5
Delay discounting water rate 18 sec	19.1	1	0	0	0	1.00e+00	Syt5
Delay discounting water rate 24 sec	7.99	1	0	0	0	1.00e+00	Syt5
Locomotor activity	6.58	1	0	0	0	1.00e+00	Rbks
Light reinforcement 1	21.59	1	1	20	0	1.00e+00	Syt5
Light reinforcement 2	14.11	2	1	20	0	1.00e+00	Supt7l Syt5
Reaction time num false alarms AUC	10.57	1	0	0	0	1.00e+00	Syt5
Reaction time mean	5.11	1	0	0	0	1.00e+00	Syt5
Reaction time mean AUC	6.17	1	0	0	0	1.00e+00	Syt5
Median of all reaction times	6.98	1	0	0	0	1.00e+00	Syt5
Reaction time omissions	5.26	1	0	0	0	1.00e+00	Syt5
Social response proportion	7.98	1	0	0	0	1.00e+00	Syt5
Social time	12.26	2	0	0	0	1.00e+00	Rbks Syt5
Conditioned locomotion	5.89	1	0	0	0	1.00e+00	Syt5
Cocaine response after cond. corrected	18.2	1	0	0	0	1.00e+00	Syt5
Cocaine response after cond. not corrected	16.42	1	0	0	0	1.00e+00	Syt5
Saline control response	13.17	1	0	0	0	1.00e+00	Syt5
Condit. Reinf. lever presses	9.91	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. change in total contacts	5.83	1	0	0	0	1.00e+00	Syt5
Conditioned reinforcement - actives	13.94	3	0	0	0	1.00e+00	Rbks Syt5 AABR07063281.1
Conditioned reinforcement - inactives	15.36	4	1	20	0.94	5.61e-02	Rbks Supt7l Apeh AABR07063281.1
Conditioned locomotion	10.54	3	0	0	0	1.00e+00	Rbks Syt5 AABR07063281.1
Intermittent access intake day 1-15 change	14.52	3	1	20	0	1.00e+00	Rbks Syt5 Apeh
Intermittent access intake escalation	15.42	2	0	0	0	1.00e+00	Rbks Apeh
Intermittent access intake escalation 2	16.13	3	1	20	0	1.00e+00	Rbks Supt7l Apeh
Intermitt. access day 1 inactive lever presses	13.18	3	0	0	0	1.00e+00	Rbks Supt7l Syt5
Intermitt. access escalation Index	17.22	1	0	0	0	1.00e+00	Syt5
Intermittent access day 1 total infusions	6.16	1	0	0	0	1.00e+00	AABR07063281.1
Intermittent access day 15 total infusions	8.06	2	0	0	0	1.00e+00	Rbks AABR07063281.1
Intermittent access terminal intake (last 3 days)	7.56	2	0	0	0	1.00e+00	Rbks AABR07063281.1
Intermittent access standard deviation	21.83	2	1	20	0	1.00e+00	Syt5 Apeh
Cocaine induced anxiety	6.44	1	0	0	0	1.00e+00	Apeh
Post-drug Anxiety	10.17	1	0	0	0	1.00e+00	Syt5
Baseline Anxiety	26.3	1	1	20	0	1.00e+00	Syt5
Lifetime Intake	6.31	1	0	0	0	1.00e+00	AABR07063281.1
Incentive Sensitization - Responses	8.7	1	0	0	0	1.00e+00	Apeh
Incentive Sensitization - Breakpoint	8.71	2	0	0	0	1.00e+00	Syt5 Apeh
Progressive ratio test 1 active lever presses	8.69	2	0	0	0	1.00e+00	Apeh AABR07063281.1
Progressive ratio test 1 breakpoint	10.22	1	0	0	0	1.00e+00	Apeh
Progressive ratio test 1 inactive lever presses	13.99	3	0	0	0.99	1.35e-02	Rbks Apeh AABR07063281.1
Progressive ratio test 2 inactive lever presses	16.94	4	1	20	0.96	1.07e-02	Rbks Supt7l Apeh AABR07063281.1
Total sessions with >9 infusions	8.88	3	0	0	0	1.00e+00	Rbks Apeh AABR07063281.1
Short access day 1 total inactive lever presses	12.74	5	1	20	0.99	1.98e-03	Rbks Supt7l Syt5 Apeh AABR07063281.1
Short access day 10 total inactive lever presses	23.86	2	1	20	0	1.00e+00	Supt7l Apeh
Short access day 1 total infusions	11.46	2	0	0	0	1.00e+00	Rbks AABR07063281.1
Short access total infusions	8.24	1	0	0	0	1.00e+00	AABR07063281.1
Short access day 1 locomotion	13.29	1	0	0	0	1.00e+00	AABR07063281.1
Short access day 10 total locomotion	8.78	2	0	0	0	1.00e+00	Syt5 Apeh
Short access total locomotion	11.85	2	0	0	0	1.00e+00	Syt5 Apeh
Compulsive drug intake	7.66	1	0	0	0	1.00e+00	Apeh
One hour access (shock baseline)	24.39	1	1	20	0	1.00e+00	Syt5
Number of responses in last shaping day	10.92	2	0	0	0	1.00e+00	Syt5 Apeh
Locomotion velocity, session 1	61.51	1	1	20	0	1.00e+00	Syt5
Locomotion distance, session 1	22.42	1	1	20	0	1.00e+00	Syt5
Locomotion velocity, session 2	20.55	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 2	5.4	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 3	8.71	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 7	10.24	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, session 8	15.73	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1.00e+00	Syt5
Time in familiar zone, hab. session 1	12.82	1	0	0	0	1.00e+00	Syt5
Total zone transitions, hab. session 1	25.53	1	1	20	0	1.00e+00	Syt5
Total locomotion distance, hab. session 1	19.26	1	1	20	0	1.00e+00	Syt5
Locomotion velocity, hab. session 1	12.27	1	0	0	0	1.00e+00	Syt5
Time in familiar zone, hab. session 2	14.1	1	0	0	0	1.00e+00	Syt5
Total zone transitions, hab. session 2	7.86	1	0	0	0	1.00e+00	Syt5
Total locomotion distance, hab. session 2	10.72	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, hab. session 2	13.63	1	0	0	0	1.00e+00	Syt5
Novelty place preference	7.01	1	0	0	0	1.00e+00	Apeh
Time in novel zone, NPP test	6.78	1	0	0	0	1.00e+00	Apeh
Pavlov. Cond. magazine entry latency	10.45	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. intertrial magazine entries	19.53	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. response bias	13.37	1	0	0	0	1.00e+00	Syt5
Bone: cortical porosity	7.72	1	0	0	0	1.00e+00	Syt5
Bone: elastic displacement	7.66	1	0	0	0	1.00e+00	Syt5
Bone: elastic work	5.83	1	0	0	0	1.00e+00	Syt5
Bone: post-yield work	11.59	1	0	0	0	1.00e+00	Syt5
Bone: stiffness	4.47	1	0	0	0	1.00e+00	Syt5
Bone: tissue strength	13.13	1	0	0	0	1.00e+00	Syt5
Bone: trabecular tissue density	8.22	1	0	0	0	1.00e+00	Syt5
Distance traveled before self-admin	57.56	1	1	20	0	1.00e+00	Syt5
Distance traveled after self-admin	56.65	1	1	20	0	1.00e+00	Syt5
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1.00e+00	Syt5
Diff in mean of infusions in LGA sessions	20.43	1	0	0	0	1.00e+00	Syt5
Extinction: sum of active levers before priming	36.46	1	1	20	0	1.00e+00	Syt5
Active lever presses in extinction session 6	17.94	1	0	0	0	1.00e+00	Syt5
Time in closed arm after self-admin	22.26	1	0	0	0	1.00e+00	Syt5
Time in open arm after self-admin	17.09	1	0	0	0	1.00e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	0	1.00e+00	Syt5
Time to tail flick, test, before self-admin	57.17	1	1	20	0	1.00e+00	Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1.00e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	20	0	1.00e+00	Syt5
Ambulatory time before self-admin	23.48	2	1	20	0	1.00e+00	Syt5 Apeh
Ambulatory time after self-admin	61.31	1	1	20	0	1.00e+00	Syt5
Area under the delay curve	15.31	1	0	0	0	1.00e+00	Rbks
Delay disc. indifference point, 0s delay	17.6	3	1	20	0	1.00e+00	Rbks Syt5 AABR07063281.1
Delay disc. indifference point, 16s delay	17.24	2	0	0	0	1.00e+00	Rbks Syt5
Delay disc. indifference point, 24s delay	13.33	4	0	0	-0.62	2.69e-01	Rbks Supt7l Syt5 AABR07063281.1
Delay disc. indifference point, 8s delay	13.89	1	0	0	0	1.00e+00	Rbks
Delay discount exponential model param	15.18	1	0	0	0	1.00e+00	Rbks
Delay discount hyperbolic model param	11.02	1	0	0	0	1.00e+00	Rbks
Time >=10cm from walls, locomotor time 1	8.08	1	0	0	0	1.00e+00	Rbks
Bouts of movement, locomotor time 1	56.89	1	1	20	0	1.00e+00	Syt5
Total resting periods, locomotor time 1	37.3	1	1	20	0	1.00e+00	Syt5
Vertical activity count, locomotor time 1	24.22	1	0	0	0	1.00e+00	Syt5
Rest time, locomotor task time 2	9.12	1	0	0	0	1.00e+00	Syt5
Weight adjusted by age	8.26	1	0	0	0	1.00e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	29.67	1	1	20	0	1.00e+00	Syt5
Locomotion in novel chamber	12.66	1	0	0	0	1.00e+00	Syt5
Progressive ratio	7.56	1	0	0	0	1.00e+00	Syt5
Food seeking constrained by brief footshock	71.06	2	1	20	0	1.00e+00	Syt5 AABR07063281.1
Seeking ratio, punishment vs. effort	16.51	1	0	0	0	1.00e+00	Syt5
Run reversals in cocaine runway, females	8.33	1	0	0	0	1.00e+00	Syt5
Cd content in liver	7.7	1	0	0	0	1.00e+00	Syt5
Co content in liver	19.37	1	0	0	0	1.00e+00	Syt5
Rb content in liver	6.49	1	0	0	0	1.00e+00	Syt5
Sr content in liver	66.74	1	1	20	0	1.00e+00	Syt5
Zn content in liver	12.43	1	0	0	0	1.00e+00	Syt5

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.12
Adipose	alternative TSS	0	1.16
Adipose	gene expression	0	1.08
Adipose	isoform ratio	0	1.11
Adipose	intron excision ratio	1	1.09
Adipose	mRNA stability	0	1.06
BLA	alternative polyA	0	1.18
BLA	alternative TSS	0	1.1
BLA	gene expression	0	1.1
BLA	isoform ratio	0	1.17
BLA	intron excision ratio	0	1.11
BLA	mRNA stability	1	1.14
Brain	alternative polyA	0	1.16
Brain	alternative TSS	0	1.19
Brain	gene expression	0	1.06
Brain	isoform ratio	0	1.12
Brain	intron excision ratio	1	1.09
Brain	mRNA stability	1	1.1
Eye	alternative polyA	0	1.42
Eye	alternative TSS	0	0.91
Eye	gene expression	0	1.03
Eye	isoform ratio	0	0.97
Eye	intron excision ratio	0	1.05
Eye	mRNA stability	0	1.15
IL	alternative polyA	0	1.24
IL	alternative TSS	0	1
IL	gene expression	0	1.09
IL	isoform ratio	0	1.21
IL	intron excision ratio	0	1.11
IL	mRNA stability	0	1.18
LHb	alternative polyA	0	1.08
LHb	alternative TSS	0	1.04
LHb	gene expression	0	1.13
LHb	isoform ratio	0	1.09
LHb	intron excision ratio	0	1.13
LHb	mRNA stability	0	1.16
Liver	alternative polyA	0	1.16
Liver	alternative TSS	0	1.19
Liver	gene expression	0	1.05
Liver	isoform ratio	0	1.13
Liver	intron excision ratio	0	1.14
Liver	mRNA stability	0	1.09
NAcc	alternative polyA	0	1.2
NAcc	alternative TSS	0	1.08
NAcc	gene expression	0	1.08
NAcc	isoform ratio	0	1.16
NAcc	intron excision ratio	1	1.19
NAcc	mRNA stability	0	1.13
OFC	alternative polyA	0	1.18
OFC	alternative TSS	0	1.32
OFC	gene expression	0	1.1
OFC	isoform ratio	0	1.11
OFC	intron excision ratio	0	1.1
OFC	mRNA stability	0	1.09
PL	alternative polyA	0	1.13
PL	alternative TSS	0	1.11
PL	gene expression	0	1.08
PL	isoform ratio	0	1.15
PL	intron excision ratio	0	1.14
PL	mRNA stability	1	1.13