Project: dissection
191 significantly associated models · 38 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 5 | 137682119 | 138752373 | 1 | 1 | 1.2e-09 | 3.1e-02 | 0.66 | 96 | Stk40 |
| 2 | 14 | 78047795 | 81951313 | 37 | 6 | 8.4e-13 | 2.2e-09 | 1.00 | 100 | Mtmr3 Nf2 Nefh Ap1b1 Ewsr1 Urgcp |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| body_g | 4.0 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| EDL weight in grams | 3.6 | 8 | 0 | 0 | 0.78 | 0.0018 | Ewsr1 Xbp1 Mrps24 Dbnl Pgam2 Polm Stk40 Nudcd3 |
| sol weight in grams | 14.0 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| pavca_mi_d3_magazine_ncs | 20.8 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| pavca_mi_d1_prob_lev | 11.8 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| pavca_mi_d1_avg_lev_lat | 12.3 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc15 | 11.2 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc21 | 17.1 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc14 | 16.5 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc4 | 14.8 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc10 | 24.5 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc5 | 23.1 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc14 | 11.2 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc12 | 13.8 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mcs | 17.3 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc4 | 18.0 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc10 | 80.6 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc11 | 85.1 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc6 | 40.1 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc17 | 13.2 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc1 | 31.5 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_spc18 | 46.6 | 1 | 1 | 14 | 0.00 | 1.0000 | Stk40 |
| tautz: manual_mpc11 | 17.2 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
| Liver selenium concentration | 12.7 | 1 | 0 | 0 | 0.00 | 1.0000 | Stk40 |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 2 | 0.094 | 1.4 |
| Adipose | alternative TSS | 1 | 0.062 | 1.4 |
| Adipose | gene expression | 12 | 0.145 | 1.5 |
| Adipose | isoform ratio | 3 | 0.106 | 1.5 |
| Adipose | intron excision ratio | 3 | 0.103 | 1.8 |
| Adipose | mRNA stability | 6 | 0.174 | 1.5 |
| BLA | alternative polyA | 0 | 0.000 | 1.4 |
| BLA | alternative TSS | 0 | 0.000 | 1.5 |
| BLA | gene expression | 5 | 0.083 | 1.5 |
| BLA | isoform ratio | 2 | 0.114 | 1.6 |
| BLA | intron excision ratio | 4 | 0.134 | 1.6 |
| BLA | mRNA stability | 2 | 0.099 | 1.5 |
| Brain | alternative polyA | 0 | 0.000 | 1.4 |
| Brain | alternative TSS | 2 | 0.116 | 1.5 |
| Brain | gene expression | 14 | 0.155 | 1.5 |
| Brain | isoform ratio | 6 | 0.190 | 1.6 |
| Brain | intron excision ratio | 8 | 0.148 | 1.7 |
| Brain | mRNA stability | 7 | 0.160 | 1.5 |
| Eye | alternative polyA | 0 | 0.000 | 1.4 |
| Eye | alternative TSS | 0 | 0.000 | 1.4 |
| Eye | gene expression | 1 | 0.089 | 1.6 |
| Eye | isoform ratio | 5 | 1.412 | 2.2 |
| Eye | intron excision ratio | 0 | 0.000 | 1.5 |
| Eye | mRNA stability | 1 | 0.431 | 1.8 |
| IL | alternative polyA | 0 | 0.000 | 1.4 |
| IL | alternative TSS | 0 | 0.000 | 1.2 |
| IL | gene expression | 4 | 0.110 | 1.5 |
| IL | isoform ratio | 2 | 0.253 | 1.6 |
| IL | intron excision ratio | 0 | 0.000 | 1.4 |
| IL | mRNA stability | 3 | 0.270 | 1.5 |
| LHb | alternative polyA | 0 | 0.000 | 1.5 |
| LHb | alternative TSS | 0 | 0.000 | 1.4 |
| LHb | gene expression | 5 | 0.156 | 1.5 |
| LHb | isoform ratio | 3 | 0.398 | 1.6 |
| LHb | intron excision ratio | 0 | 0.000 | 1.7 |
| LHb | mRNA stability | 3 | 0.290 | 1.6 |
| Liver | alternative polyA | 0 | 0.000 | 1.3 |
| Liver | alternative TSS | 4 | 0.264 | 1.5 |
| Liver | gene expression | 9 | 0.125 | 1.5 |
| Liver | isoform ratio | 6 | 0.251 | 1.5 |
| Liver | intron excision ratio | 5 | 0.114 | 1.6 |
| Liver | mRNA stability | 4 | 0.163 | 1.6 |
| NAcc | alternative polyA | 0 | 0.000 | 1.4 |
| NAcc | alternative TSS | 0 | 0.000 | 1.4 |
| NAcc | gene expression | 1 | 0.030 | 1.5 |
| NAcc | isoform ratio | 2 | 0.269 | 1.6 |
| NAcc | intron excision ratio | 0 | 0.000 | 1.6 |
| NAcc | mRNA stability | 4 | 0.370 | 1.5 |
| NAcc2 | alternative polyA | 1 | 0.090 | 1.4 |
| NAcc2 | alternative TSS | 0 | 0.000 | 1.5 |
| NAcc2 | gene expression | 2 | 0.037 | 1.5 |
| NAcc2 | isoform ratio | 4 | 0.259 | 1.6 |
| NAcc2 | intron excision ratio | 4 | 0.151 | 1.6 |
| NAcc2 | mRNA stability | 3 | 0.168 | 1.4 |
| OFC | alternative polyA | 0 | 0.000 | 1.4 |
| OFC | alternative TSS | 0 | 0.000 | 1.4 |
| OFC | gene expression | 4 | 0.108 | 1.5 |
| OFC | isoform ratio | 2 | 0.245 | 1.7 |
| OFC | intron excision ratio | 0 | 0.000 | 1.7 |
| OFC | mRNA stability | 5 | 0.463 | 1.5 |
| PL | alternative polyA | 0 | 0.000 | 1.4 |
| PL | alternative TSS | 0 | 0.000 | 1.1 |
| PL | gene expression | 4 | 0.108 | 1.5 |
| PL | isoform ratio | 2 | 0.230 | 1.7 |
| PL | intron excision ratio | 1 | 0.096 | 1.6 |
| PL | mRNA stability | 4 | 0.348 | 1.6 |
| PL2 | alternative polyA | 0 | 0.000 | 1.5 |
| PL2 | alternative TSS | 0 | 0.000 | 1.4 |
| PL2 | gene expression | 6 | 0.094 | 1.5 |
| PL2 | isoform ratio | 3 | 0.163 | 1.6 |
| PL2 | intron excision ratio | 4 | 0.127 | 1.7 |
| PL2 | mRNA stability | 3 | 0.123 | 1.5 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.