Hub : Traits

Delay discounting water rate 18 sec

Delay discounting using a sequential patch depletion procedure, water consumption rate during the last two sessions with an experimenter-imposed delay of 18 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

1 loci · 1 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	140614300	142727457	2	1	1.95e-10	3.55e-09	3.56e-01	Grm5

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Left kidney weight	2.83	2	0	0	0	1.00e+00	Grm5 Ctsc
Liver weight, right	5.25	1	0	0	0	1.00e+00	Grm5
Intraocular pressure	12.93	2	0	0	1	5.02e-11	Grm5 Ctsc
Mean time between licks in bursts	7.43	2	0	0	-1	1.68e-06	Grm5 Ctsc
Delay discounting time to switch 0 sec	9.4	2	0	0	-1	3.48e-10	Grm5 Ctsc
Delay discounting water rate 0 sec	6.72	2	0	0	1	1.04e-05	Grm5 Ctsc
Delay discounting water rate 12 sec	14.2	2	2	200	1	9.69e-10	Grm5 Ctsc
Delay discounting water rate 24 sec	7.48	2	0	0	1	9.40e-10	Grm5 Ctsc
Delay discounting water rate 6 sec	8.05	2	0	0	1	8.38e-11	Grm5 Ctsc
Locomotor activity	5.38	2	0	0	1	4.04e-04	Grm5 Ctsc
Light reinforcement 1	11.43	2	0	0	-0.99	4.97e-08	Grm5 Ctsc
Light reinforcement 2	21.05	2	2	200	-0.98	1.89e-06	Grm5 Ctsc
Reaction time num false alarms	14.54	2	0	0	-1	1.14e-09	Grm5 Ctsc
Reaction time num false alarms AUC	11.26	2	0	0	-1	6.03e-10	Grm5 Ctsc
Reaction time false alarm rate	14.51	2	0	0	-1	2.16e-10	Grm5 Ctsc
Short access day 1 total infusions	8.71	2	0	0	-1	1.95e-06	Grm5 Ctsc
Locomotion velocity, session 1	16.38	2	0	0	0.99	1.58e-07	Grm5 Ctsc
Locomotion velocity, session 2	7.99	2	0	0	1	3.23e-05	Grm5 Ctsc
Locomotion distance, session 3	10.09	2	0	0	1	2.83e-05	Grm5 Ctsc
Stereotopy head waving bouts, day 3	9.35	2	0	0	-0.99	2.20e-07	Grm5 Ctsc
Locomotion velocity, session 8	7.86	2	0	0	1	5.75e-09	Grm5 Ctsc
Total zone transitions, hab. session 1	7.2	2	0	0	1	2.50e-04	Grm5 Ctsc
Total locomotion distance, hab. session 1	29.05	2	2	200	-0.99	4.82e-07	Grm5 Ctsc
Locomotion velocity, hab. session 1	29.6	2	2	200	-0.99	6.42e-07	Grm5 Ctsc
Total locomotion distance, hab. session 2	37.16	2	2	200	-0.99	5.65e-07	Grm5 Ctsc
Locomotion velocity, hab. session 2	34.18	2	2	200	-0.99	8.17e-07	Grm5 Ctsc
Total locomotion distance, NPP test	39.25	2	2	200	-0.98	1.37e-06	Grm5 Ctsc
Locomotion velocity, NPP test	37.86	2	2	200	-0.98	1.42e-06	Grm5 Ctsc
Bone: minimum diameter	4.22	1	0	0	0	1.00e+00	Ctsc
Time to tail flick, vehicle, after self-admin	8.02	1	0	0	0	1.00e+00	Grm5
Vertical activity count, locomotor time 2	9.1	2	0	0	0	1.00e+00	Grm5 Ctsc
Latency to leave start box in cocaine runway	10.82	2	0	0	-0.99	4.15e-07	Grm5 Ctsc
Latency to leave start box in cocaine runway, F	9.55	1	0	0	0	1.00e+00	Ctsc
Latency to leave start box in cocaine runway, M	8.78	2	0	0	0	1.00e+00	Grm5 Ctsc
Cd content in liver	7.68	2	0	0	-1	2.42e-07	Grm5 Ctsc

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.3
Adipose	alternative TSS	0	0	1.27
Adipose	gene expression	0	0	1.31
Adipose	isoform ratio	0	0	1.26
Adipose	intron excision ratio	0	0	1.34
Adipose	mRNA stability	0	0	1.31
BLA	alternative polyA	2	0.2	1.39
BLA	alternative TSS	0	0	1.33
BLA	gene expression	1	0	1.33
BLA	isoform ratio	0	0	1.27
BLA	intron excision ratio	0	0	1.35
BLA	mRNA stability	1	0	1.35
Brain	alternative polyA	0	0	1.3
Brain	alternative TSS	0	0	1.31
Brain	gene expression	1	0	1.36
Brain	isoform ratio	1	0	1.25
Brain	intron excision ratio	0	0	1.38
Brain	mRNA stability	0	0	1.33
Eye	alternative polyA	0	0	1.02
Eye	alternative TSS	0	0	1.05
Eye	gene expression	1	0.1	1.24
Eye	isoform ratio	0	0	1.24
Eye	intron excision ratio	0	0	1.18
Eye	mRNA stability	0	0	1.22
IL	alternative polyA	0	0	1.45
IL	alternative TSS	0	0	1.18
IL	gene expression	1	0	1.33
IL	isoform ratio	0	0	1.3
IL	intron excision ratio	0	0	1.42
IL	mRNA stability	0	0	1.35
LHb	alternative polyA	0	0	1.27
LHb	alternative TSS	0	0	1.38
LHb	gene expression	0	0	1.36
LHb	isoform ratio	0	0	1.42
LHb	intron excision ratio	0	0	1.33
LHb	mRNA stability	0	0	1.3
Liver	alternative polyA	0	0	1.34
Liver	alternative TSS	0	0	1.25
Liver	gene expression	0	0	1.36
Liver	isoform ratio	0	0	1.3
Liver	intron excision ratio	0	0	1.28
Liver	mRNA stability	0	0	1.29
NAcc	alternative polyA	0	0	1.32
NAcc	alternative TSS	0	0	1.35
NAcc	gene expression	0	0	1.33
NAcc	isoform ratio	0	0	1.34
NAcc	intron excision ratio	0	0	1.34
NAcc	mRNA stability	0	0	1.34
OFC	alternative polyA	0	0	1.37
OFC	alternative TSS	0	0	1.31
OFC	gene expression	0	0	1.33
OFC	isoform ratio	0	0	1.33
OFC	intron excision ratio	0	0	1.28
OFC	mRNA stability	0	0	1.35
PL	alternative polyA	0	0	1.39
PL	alternative TSS	0	0	1.37
PL	gene expression	0	0	1.35
PL	isoform ratio	0	0	1.35
PL	intron excision ratio	0	0	1.29
PL	mRNA stability	1	0	1.34