Delay discounting time to switch 0 sec

Delay discounting using a sequential patch depletion procedure, time it took the rat to switch water feeders with an experimenter-imposed delay of 0 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

3 loci · 3 genes with independent associations · 6 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	2.57e-20	8.49e-05	1.34e-46	Syt5
2	6	68065049	70118374	4	1	3.81e-08	1.07e-06	2.23e-01	G2e3
3	6	70976798	72372377	1	1	1.29e-07	2.76e-07	1.00e+00	Egln3

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
Body weight	2.58	1	0	0	0	1.00e+00	Syt5
Glucose	12.08	1	0	0	0	1.00e+00	Syt5
Liver weight, left	10.21	1	0	0	0	1.00e+00	Syt5
Liver weight, right	11.2	1	0	0	0	1.00e+00	Syt5
Retroperitoneal fat weight	3.14	3	0	0	1	1.34e-03	G2e3 Egln3 Scfd1
Tibia length	7.53	1	0	0	0	1.00e+00	Syt5
Std. dev. time between licks in bursts	22.72	1	1	33.3	0	1.00e+00	Syt5
Indifference point 0 sec	7.03	2	0	0	0	1.00e+00	Egln3 Syt5
Indifference point AUC	10.46	1	0	0	0	1.00e+00	G2e3
Indifference point function ln k	8.79	1	0	0	0	1.00e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 0 sec	6.48	3	0	0	0	1.00e+00	G2e3 Egln3 Syt5
Delay discounting total patch changes 12 sec	7.55	1	0	0	0	1.00e+00	G2e3
Delay discounting total patch changes 24 sec	10.35	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 6 sec	6.91	1	0	0	0	1.00e+00	G2e3
Delay discounting water rate 0 sec	6.87	6	0	0	-0.98	1.78e-07	G2e3 Egln3 Heatr5a Hectd1 Syt5 Scfd1
Delay discounting water rate 12 sec	22.12	1	1	33.3	0	1.00e+00	Syt5
Delay discounting water rate 18 sec	19.1	1	0	0	0	1.00e+00	Syt5
Delay discounting water rate 24 sec	7.99	1	0	0	0	1.00e+00	Syt5
Delay discounting water rate 6 sec	6.64	3	0	0	-0.82	2.51e-02	G2e3 Heatr5a Hectd1
Locomotor activity	6.25	3	0	0	0.72	2.83e-01	G2e3 Heatr5a Hectd1
Light reinforcement 1	21.59	1	1	33.3	0	1.00e+00	Syt5
Light reinforcement 2	21.57	1	1	33.3	0	1.00e+00	Syt5
Reaction time num false alarms	7.16	1	0	0	0	1.00e+00	Egln3
Reaction time num false alarms AUC	9.55	2	0	0	0	1.00e+00	Egln3 Syt5
Reaction time mean AUC	6.17	1	0	0	0	1.00e+00	Syt5
Median of all reaction times	6.98	1	0	0	0	1.00e+00	Syt5
Reaction time false alarm rate	6.47	1	0	0	0	1.00e+00	Egln3
Social response proportion	7.98	1	0	0	0	1.00e+00	Syt5
Social time	18.13	1	0	0	0	1.00e+00	Syt5
Cocaine response after cond. corrected	18.2	1	0	0	0	1.00e+00	Syt5
Cocaine response after cond. not corrected	16.42	1	0	0	0	1.00e+00	Syt5
Saline control response	13.17	1	0	0	0	1.00e+00	Syt5
Condit. Reinf. lever presses	9.91	1	0	0	0	1.00e+00	Syt5
Conditioned reinforcement - actives	22.28	1	0	0	0	1.00e+00	Syt5
Conditioned locomotion	15.14	1	0	0	0	1.00e+00	Syt5
Intermitt. access day 1 inactive lever presses	19.07	1	0	0	0	1.00e+00	Syt5
Intermitt. access day 15 inactive lever presses	38.52	1	1	33.3	0	1.00e+00	Syt5
Intermitt. access escalation Index	17.22	1	0	0	0	1.00e+00	Syt5
Intermittent access standard deviation	9.35	1	0	0	0	1.00e+00	Syt5
Post-drug Anxiety	10.17	1	0	0	0	1.00e+00	Syt5
Baseline Anxiety	26.3	1	1	33.3	0	1.00e+00	Syt5
Incentive Sensitization - Breakpoint	8.61	1	0	0	0	1.00e+00	Syt5
Short access day 1 total inactive lever presses	24.45	1	1	33.3	0	1.00e+00	Syt5
Short access day 10 total locomotion	11.18	1	0	0	0	1.00e+00	Syt5
Short access total locomotion	13.05	1	0	0	0	1.00e+00	Syt5
One hour access (shock baseline)	24.39	1	1	33.3	0	1.00e+00	Syt5
Number of responses in last shaping day	9.84	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, session 1	61.51	1	1	33.3	0	1.00e+00	Syt5
Locomotion distance, session 1	22.42	1	1	33.3	0	1.00e+00	Syt5
Locomotion velocity, session 2	20.55	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 3	8.71	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, session 7	7.67	1	0	0	0	1.00e+00	Hectd1
Locomotion distance, session 7	10.24	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, session 8	15.73	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1.00e+00	Syt5
Time in familiar zone, hab. session 1	12.82	1	0	0	0	1.00e+00	Syt5
Total zone transitions, hab. session 1	25.53	1	1	33.3	0	1.00e+00	Syt5
Total locomotion distance, hab. session 1	19.26	1	1	33.3	0	1.00e+00	Syt5
Locomotion velocity, hab. session 1	12.27	1	0	0	0	1.00e+00	Syt5
Time in familiar zone, hab. session 2	14.1	1	0	0	0	1.00e+00	Syt5
Total zone transitions, hab. session 2	7.86	1	0	0	0	1.00e+00	Syt5
Total locomotion distance, hab. session 2	10.72	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, hab. session 2	13.63	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. magazine entry latency	10.45	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. intertrial magazine entries	19.53	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. response bias	13.37	1	0	0	0	1.00e+00	Syt5
Bone: cortical porosity	7.72	1	0	0	0	1.00e+00	Syt5
Bone: elastic displacement	7.66	1	0	0	0	1.00e+00	Syt5
Bone: endosteal estimation	4.08	3	0	0	-1	8.37e-04	G2e3 Egln3 Scfd1
Bone: endosteal perimeter	5.65	4	0	0	-1	2.25e-10	G2e3 Heatr5a Hectd1 Scfd1
Bone: marrow area	4.2	3	0	0	-1	8.28e-04	G2e3 Egln3 Scfd1
Bone: maximum diameter	8.07	4	0	0	-1	3.12e-11	G2e3 Heatr5a Hectd1 Scfd1
Bone: periosteal estimation	5.48	4	0	0	-1	3.97e-10	G2e3 Heatr5a Hectd1 Scfd1
Bone: periosteal perimeter	5.17	1	0	0	0	1.00e+00	G2e3
Bone: post-yield work	11.59	1	0	0	0	1.00e+00	Syt5
Bone: tissue strength	13.13	1	0	0	0	1.00e+00	Syt5
Bone: trabecular tissue density	8.22	1	0	0	0	1.00e+00	Syt5
Distance traveled before self-admin	57.56	1	1	33.3	0	1.00e+00	Syt5
Distance traveled after self-admin	56.65	1	1	33.3	0	1.00e+00	Syt5
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1.00e+00	Syt5
Diff in mean of infusions in LGA sessions	20.43	1	0	0	0	1.00e+00	Syt5
Extinction: sum of active levers before priming	36.46	1	1	33.3	0	1.00e+00	Syt5
Active lever presses in extinction session 6	17.94	1	0	0	0	1.00e+00	Syt5
Time in closed arm after self-admin	22.26	1	0	0	0	1.00e+00	Syt5
Time in open arm after self-admin	17.09	1	0	0	0	1.00e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	0	1.00e+00	Syt5
Time to tail flick, test, before self-admin	57.17	1	1	33.3	0	1.00e+00	Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1.00e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	33.3	0	1.00e+00	Syt5
Ambulatory time before self-admin	36.65	1	1	33.3	0	1.00e+00	Syt5
Ambulatory time after self-admin	61.31	1	1	33.3	0	1.00e+00	Syt5
Area under the delay curve	8.88	1	0	0	0	1.00e+00	Egln3
Delay disc. indifference point, 0s delay	27.96	1	1	33.3	0	1.00e+00	Syt5
Delay disc. indifference point, 16s delay	24.13	1	0	0	0	1.00e+00	Syt5
Delay disc. indifference point, 24s delay	9.61	1	0	0	0	1.00e+00	Syt5
Bouts of movement, locomotor time 1	56.89	1	1	33.3	0	1.00e+00	Syt5
Total resting periods, locomotor time 1	37.3	1	1	33.3	0	1.00e+00	Syt5
Vertical activity count, locomotor time 1	24.22	1	0	0	0	1.00e+00	Syt5
Rest time, locomotor task time 2	9.12	1	0	0	0	1.00e+00	Syt5
Weight adjusted by age	8.26	1	0	0	0	1.00e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	29.67	1	1	33.3	0	1.00e+00	Syt5
Locomotion in novel chamber	12.66	1	0	0	0	1.00e+00	Syt5
Progressive ratio	7.56	1	0	0	0	1.00e+00	Syt5
Food seeking constrained by brief footshock	133.39	1	1	33.3	0	1.00e+00	Syt5
Seeking ratio, punishment vs. effort	16.51	1	0	0	0	1.00e+00	Syt5
Run reversals in cocaine runway, females	8.33	1	0	0	0	1.00e+00	Syt5
Cd content in liver	7.7	1	0	0	0	1.00e+00	Syt5
Co content in liver	19.37	1	0	0	0	1.00e+00	Syt5
Sr content in liver	66.74	1	1	33.3	0	1.00e+00	Syt5
Zn content in liver	12.43	1	0	0	0	1.00e+00	Syt5

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.5
Adipose	alternative TSS	0	0	1.52
Adipose	gene expression	0	0	1.52
Adipose	isoform ratio	0	0	1.47
Adipose	intron excision ratio	0	0	1.57
Adipose	mRNA stability	0	0	1.48
BLA	alternative polyA	0	0	1.47
BLA	alternative TSS	0	0	1.45
BLA	gene expression	2	0	1.55
BLA	isoform ratio	0	0	1.53
BLA	intron excision ratio	0	0	1.62
BLA	mRNA stability	2	0.1	1.62
Brain	alternative polyA	0	0	1.49
Brain	alternative TSS	0	0	1.47
Brain	gene expression	1	0	1.51
Brain	isoform ratio	0	0	1.47
Brain	intron excision ratio	0	0	1.6
Brain	mRNA stability	1	0	1.47
Eye	alternative polyA	0	0	1.64
Eye	alternative TSS	0	0	1.31
Eye	gene expression	0	0	1.53
Eye	isoform ratio	0	0	1.44
Eye	intron excision ratio	0	0	1.68
Eye	mRNA stability	0	0	1.65
IL	alternative polyA	0	0	1.56
IL	alternative TSS	0	0	1.95
IL	gene expression	0	0	1.52
IL	isoform ratio	0	0	1.62
IL	intron excision ratio	0	0	1.63
IL	mRNA stability	0	0	1.6
LHb	alternative polyA	0	0	1.36
LHb	alternative TSS	0	0	1.46
LHb	gene expression	1	0	1.52
LHb	isoform ratio	0	0	1.57
LHb	intron excision ratio	0	0	1.48
LHb	mRNA stability	0	0	1.51
Liver	alternative polyA	0	0	1.6
Liver	alternative TSS	0	0	1.41
Liver	gene expression	0	0	1.53
Liver	isoform ratio	0	0	1.53
Liver	intron excision ratio	0	0	1.58
Liver	mRNA stability	1	0	1.47
NAcc	alternative polyA	0	0	1.38
NAcc	alternative TSS	0	0	1.43
NAcc	gene expression	1	0	1.54
NAcc	isoform ratio	0	0	1.48
NAcc	intron excision ratio	1	0	1.61
NAcc	mRNA stability	0	0	1.59
OFC	alternative polyA	0	0	1.38
OFC	alternative TSS	0	0	1.48
OFC	gene expression	1	0	1.48
OFC	isoform ratio	0	0	1.72
OFC	intron excision ratio	0	0	1.52
OFC	mRNA stability	0	0	1.58
PL	alternative polyA	0	0	1.55
PL	alternative TSS	0	0	1.53
PL	gene expression	1	0	1.51
PL	isoform ratio	0	0	1.5
PL	intron excision ratio	0	0	1.59
PL	mRNA stability	0	0	1.56