Project: p50_paul_meyer_2020
3 significantly associated models · 2 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 187833756 | 189718769 | 2 | 1 | 7.8e-08 | 2e-09 | 0.0016 | 72 | Adam12 |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| retroperitoneal_fat_g | 2.1 | 1 | 0 | 0 | 0 | 1 | Uros |
| dissection: PC 3 of all traits | 5.1 | 1 | 0 | 0 | 0 | 1 | Uros |
| Tibia length in mm | 3.4 | 1 | 0 | 0 | 0 | 1 | Uros |
| Times rat made contact with spout | 5.5 | 1 | 0 | 0 | 0 | 1 | Uros |
| Average drop size | 10.9 | 1 | 0 | 0 | 0 | 1 | Uros |
| locomotor_testing_activity | 4.3 | 1 | 0 | 0 | 0 | 1 | Uros |
| ccp_trial_3_saline_dist_mm | 7.0 | 1 | 0 | 0 | 0 | 1 | Uros |
| Total sessions with >9 infusions | 9.9 | 2 | 0 | 0 | 0 | 1 | Uros Adam12 |
| crf_mi_active_responses | 4.9 | 1 | 0 | 0 | 0 | 1 | Adam12 |
| tautz: manual_spc12 | 11.8 | 1 | 0 | 0 | 0 | 1 | Uros |
| tautz: manual_spc8 | 5.1 | 1 | 0 | 0 | 0 | 1 | Adam12 |
| tautz: manual_mpc6 | 5.2 | 2 | 0 | 0 | 0 | 1 | Uros Adam12 |
| tautz: manual_mpc8 | 5.1 | 1 | 0 | 0 | 0 | 1 | Adam12 |
| Ambulatory time at time1 of open field | 10.4 | 2 | 0 | 0 | 0 | 1 | Uros Adam12 |
| Liver zinc concentration | 7.0 | 2 | 0 | 0 | 0 | 1 | Uros Adam12 |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 0 | 0.000 | 1.16 |
| Adipose | alternative TSS | 0 | 0.000 | 1.09 |
| Adipose | gene expression | 1 | 0.012 | 1.21 |
| Adipose | isoform ratio | 0 | 0.000 | 1.18 |
| Adipose | intron excision ratio | 0 | 0.000 | 1.14 |
| Adipose | mRNA stability | 0 | 0.000 | 1.21 |
| BLA | alternative polyA | 0 | 0.000 | 1.17 |
| BLA | alternative TSS | 0 | 0.000 | 1.18 |
| BLA | gene expression | 0 | 0.000 | 1.23 |
| BLA | isoform ratio | 0 | 0.000 | 1.27 |
| BLA | intron excision ratio | 0 | 0.000 | 1.14 |
| BLA | mRNA stability | 1 | 0.050 | 1.25 |
| Brain | alternative polyA | 0 | 0.000 | 1.14 |
| Brain | alternative TSS | 0 | 0.000 | 1.13 |
| Brain | gene expression | 0 | 0.000 | 1.21 |
| Brain | isoform ratio | 0 | 0.000 | 1.19 |
| Brain | intron excision ratio | 0 | 0.000 | 1.16 |
| Brain | mRNA stability | 0 | 0.000 | 1.18 |
| Eye | alternative polyA | 0 | 0.000 | 1.37 |
| Eye | alternative TSS | 0 | 0.000 | 1.01 |
| Eye | gene expression | 1 | 0.089 | 1.24 |
| Eye | isoform ratio | 0 | 0.000 | 1.28 |
| Eye | intron excision ratio | 0 | 0.000 | 1.09 |
| Eye | mRNA stability | 0 | 0.000 | 1.26 |
| IL | alternative polyA | 0 | 0.000 | 1.16 |
| IL | alternative TSS | 0 | 0.000 | 1.52 |
| IL | gene expression | 0 | 0.000 | 1.23 |
| IL | isoform ratio | 0 | 0.000 | 1.18 |
| IL | intron excision ratio | 0 | 0.000 | 1.13 |
| IL | mRNA stability | 0 | 0.000 | 1.27 |
| LHb | alternative polyA | 0 | 0.000 | 1.11 |
| LHb | alternative TSS | 0 | 0.000 | 1.28 |
| LHb | gene expression | 0 | 0.000 | 1.23 |
| LHb | isoform ratio | 0 | 0.000 | 1.24 |
| LHb | intron excision ratio | 0 | 0.000 | 1.13 |
| LHb | mRNA stability | 0 | 0.000 | 1.32 |
| Liver | alternative polyA | 0 | 0.000 | 1.11 |
| Liver | alternative TSS | 0 | 0.000 | 1.14 |
| Liver | gene expression | 0 | 0.000 | 1.19 |
| Liver | isoform ratio | 0 | 0.000 | 1.16 |
| Liver | intron excision ratio | 0 | 0.000 | 1.18 |
| Liver | mRNA stability | 0 | 0.000 | 1.17 |
| NAcc | alternative polyA | 0 | 0.000 | 1.15 |
| NAcc | alternative TSS | 0 | 0.000 | 1.14 |
| NAcc | gene expression | 0 | 0.000 | 1.21 |
| NAcc | isoform ratio | 0 | 0.000 | 1.27 |
| NAcc | intron excision ratio | 0 | 0.000 | 0.99 |
| NAcc | mRNA stability | 0 | 0.000 | 1.37 |
| NAcc2 | alternative polyA | 0 | 0.000 | 1.17 |
| NAcc2 | alternative TSS | 0 | 0.000 | 1.29 |
| NAcc2 | gene expression | 0 | 0.000 | 1.26 |
| NAcc2 | isoform ratio | 0 | 0.000 | 1.25 |
| NAcc2 | intron excision ratio | 0 | 0.000 | 1.13 |
| NAcc2 | mRNA stability | 0 | 0.000 | 1.32 |
| OFC | alternative polyA | 0 | 0.000 | 1.15 |
| OFC | alternative TSS | 0 | 0.000 | 1.50 |
| OFC | gene expression | 0 | 0.000 | 1.31 |
| OFC | isoform ratio | 0 | 0.000 | 1.19 |
| OFC | intron excision ratio | 0 | 0.000 | 1.27 |
| OFC | mRNA stability | 0 | 0.000 | 1.32 |
| PL | alternative polyA | 0 | 0.000 | 1.11 |
| PL | alternative TSS | 0 | 0.000 | 1.27 |
| PL | gene expression | 0 | 0.000 | 1.25 |
| PL | isoform ratio | 0 | 0.000 | 1.19 |
| PL | intron excision ratio | 0 | 0.000 | 1.31 |
| PL | mRNA stability | 0 | 0.000 | 1.32 |
| PL2 | alternative polyA | 0 | 0.000 | 1.25 |
| PL2 | alternative TSS | 0 | 0.000 | 1.19 |
| PL2 | gene expression | 0 | 0.000 | 1.23 |
| PL2 | isoform ratio | 0 | 0.000 | 1.24 |
| PL2 | intron excision ratio | 0 | 0.000 | 1.16 |
| PL2 | mRNA stability | 0 | 0.000 | 1.26 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.