Hub : Traits

Conditioned reinforcement - inactives

Tags: Behavior · Conditioned reinforcement

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	3	90392583	91787299	1	1	1.37e-08	7.89e-06	2.01e-86	Tcp11l1
2	8	108584253	109479622	1	1	1.57e-09	1.69e-02	1.08e-03	Apeh
3	11	39057816	40174684	1	1	2.03e-09	2.36e-01	1.00e+00	Epha6

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Heart weight	4.41	1	0	0	0	1e+00	Epha6
Liver weight, left	3.97	1	0	0	0	1e+00	Apeh
Parametrial fat weight	18.48	1	1	33.3	0	1e+00	Epha6
Retroperitoneal fat weight	13.87	1	1	33.3	0	1e+00	Tcp11l1
Intraocular pressure	5.23	1	0	0	0	1e+00	Epha6
Tibialis anterior weight	3.35	1	0	0	0	1e+00	Tcp11l1
Tibia length	2.39	1	0	0	0	1e+00	Epha6
Food consumed during 24 hour testing period	5.03	1	0	0	0	1e+00	Epha6
Times rat made contact with spout	14.64	1	0	0	0	1e+00	Epha6
Std. dev. time between licks in bursts	6.89	1	0	0	0	1e+00	Apeh
Water consumed over 24 hours	14.75	1	0	0	0	1e+00	Epha6
Indifference point 0 sec	3.78	1	0	0	0	1e+00	Apeh
Delay discounting total patch changes 12 sec	14.51	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 18 sec	11.09	2	0	0	0	1e+00	Epha6 Apeh
Delay discounting total patch changes 6 sec	9.24	2	0	0	0	1e+00	Epha6 Apeh
Delay discounting water rate 18 sec	10.22	1	0	0	0	1e+00	Epha6
Locomotor activity	7.92	1	0	0	0	1e+00	Epha6
Locomotor testing distance	8.93	1	0	0	0	1e+00	Epha6
Reaction time premature initiation rate	7.63	1	0	0	0	1e+00	Epha6
Reaction time premature initiations	4.08	1	0	0	0	1e+00	Epha6
Social response proportion	5.35	1	0	0	0	1e+00	Tcp11l1
Social time	5.73	1	0	0	0	1e+00	Tcp11l1
Conditioned locomotion	9.63	2	0	0	0	1e+00	Epha6 Tcp11l1
Cocaine response after cond. corrected	7.21	1	0	0	0	1e+00	Tcp11l1
Cocaine response before conditioning	5.89	2	0	0	0	1e+00	Epha6 Tcp11l1
Saline control response	4.42	1	0	0	0	1e+00	Apeh
Condit. Reinf. lever presses	6.41	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	5.89	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever contacts	7.02	1	0	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	6.55	1	0	0	0	1e+00	Epha6
Pavlov. Cond. response bias	4.45	1	0	0	0	1e+00	Epha6
Conditioned reinforcement - actives	15.36	2	0	0	0	1e+00	Epha6 Tcp11l1
Conditioned locomotion	6.08	2	0	0	0	1e+00	Apeh Tcp11l1
Intermittent access intake day 1-15 change	26.8	1	1	33.3	0	1e+00	Apeh
Intermittent access intake escalation	21.18	1	0	0	0	1e+00	Apeh
Intermittent access intake escalation 2	29.8	1	1	33.3	0	1e+00	Apeh
Intermitt. access day 1 inactive lever presses	5.75	1	0	0	0	1e+00	Tcp11l1
Intermitt. access day 15 inactive lever presses	27.39	1	1	33.3	0	1e+00	Apeh
Intermittent access day 1 total infusions	10.93	1	0	0	0	1e+00	Epha6
Intermittent access day 15 total infusions	13.64	1	0	0	0	1e+00	Epha6
Intermittent access terminal intake (last 3 days)	20.14	1	0	0	0	1e+00	Epha6
Intermittent access total infusions	18.26	1	0	0	0	1e+00	Epha6
Intermittent access standard deviation	34.31	1	1	33.3	0	1e+00	Apeh
Cocaine induced anxiety	12.04	2	0	0	0	1e+00	Epha6 Apeh
Post-drug Anxiety	5.89	1	0	0	0	1e+00	Epha6
Baseline Anxiety	13.35	2	0	0	0	1e+00	Epha6 Tcp11l1
Lifetime Intake	33.5	1	1	33.3	0	1e+00	Epha6
Incentive Sensitization - Responses	8.37	2	0	0	0	1e+00	Epha6 Apeh
Incentive Sensitization - Breakpoint	8.4	2	0	0	0	1e+00	Epha6 Apeh
Progressive ratio test 1 active lever presses	17.29	2	0	0	0	1e+00	Epha6 Apeh
Progressive ratio test 1 breakpoint	19.75	2	1	33.3	0	1e+00	Epha6 Apeh
Progressive ratio test 1 inactive lever presses	8.37	2	0	0	0	1e+00	Epha6 Apeh
Progressive ratio test 2 active lever presses	30.7	1	1	33.3	0	1e+00	Epha6
Progressive ratio test 2 breakpoint	23.99	1	1	33.3	0	1e+00	Epha6
Progressive ratio test 2 inactive lever presses	25.77	3	2	66.7	0	1e+00	Epha6 Apeh Tcp11l1
Total sessions with >9 infusions	15.49	2	0	0	0	1e+00	Epha6 Apeh
Short access day 1 total inactive lever presses	6.86	3	0	0	0	1e+00	Epha6 Apeh Tcp11l1
Short access day 10 total inactive lever presses	40.3	1	1	33.3	0	1e+00	Apeh
Short access day 1 total infusions	39.99	1	1	33.3	0	1e+00	Epha6
Short access total infusions	43.87	1	1	33.3	0	1e+00	Epha6
Short access day 10 total locomotion	6.38	1	0	0	0	1e+00	Apeh
Short access total locomotion	10.65	1	0	0	0	1e+00	Apeh
Compulsive drug intake	7.66	1	0	0	0	1e+00	Apeh
One hour access (0.3 mA shock)	36.93	1	1	33.3	0	1e+00	Epha6
One hour access (shock baseline)	19.69	1	0	0	0	1e+00	Epha6
Number of responses in last shaping day	12	1	0	0	0	1e+00	Apeh
Locomotion distance, session 1	11.43	1	0	0	0	1e+00	Epha6
Stereotopy head waving bouts, day 3	8.94	1	0	0	0	1e+00	Epha6
Locomotion velocity, session 7	7.71	1	0	0	0	1e+00	Epha6
Locomotion distance, session 7	11.27	1	0	0	0	1e+00	Epha6
Locomotion distance, session 8	5.5	1	0	0	0	1e+00	Epha6
Degree of sensitization distance	6.07	1	0	0	0	1e+00	Epha6
Condit. Reinf. active minus inactive responses	9.43	1	0	0	0	1e+00	Epha6
Condit. Reinf. active-inactive response ratio	9.45	1	0	0	0	1e+00	Epha6
Condit. Reinf. active responses	9.65	1	0	0	0	1e+00	Epha6
Incentive salience index mean	10.79	1	0	0	0	1e+00	Epha6
Condit. Reinf. lever presses	10.96	1	0	0	0	1e+00	Epha6
Time in familiar zone, hab. session 1	9.82	1	0	0	0	1e+00	Epha6
Time in novel zone, hab. session 1	6.18	1	0	0	0	1e+00	Epha6
Total zone transitions, hab. session 1	8.13	1	0	0	0	1e+00	Epha6
Total locomotion distance, hab. session 1	4.8	1	0	0	0	1e+00	Epha6
Locomotion velocity, hab. session 1	8.12	1	0	0	0	1e+00	Epha6
Time in familiar zone, hab. session 2	37.26	1	1	33.3	0	1e+00	Epha6
Time in novel zone, hab. session 2	30.02	1	1	33.3	0	1e+00	Epha6
Total zone transitions, hab. session 2	7.43	1	0	0	0	1e+00	Epha6
Total locomotion distance, hab. session 2	8.86	1	0	0	0	1e+00	Epha6
Locomotion velocity, hab. session 2	8.97	1	0	0	0	1e+00	Epha6
Novel to familiar place preference ratio	6.25	1	0	0	0	1e+00	Apeh
Novelty place preference	6.39	2	0	0	0	1e+00	Epha6 Apeh
Time in novel zone, NPP test	6.78	1	0	0	0	1e+00	Apeh
Pavlov. Cond. lever latency	19.53	1	0	0	0	1e+00	Epha6
Pavlov. Cond. magazine entry latency	20.28	2	1	33.3	0	1e+00	Epha6 Apeh
Pavlov. Cond. change in total contacts	8.22	1	0	0	0	1e+00	Epha6
Pavlov. Cond. index score	29.2	1	1	33.3	0	1e+00	Epha6
Pavlov. Cond. latency score	26.87	1	1	33.3	0	1e+00	Epha6
Pavlov. Cond. lever contacts	25.56	1	1	33.3	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	14.74	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever-magazine prob. diff.	16.22	2	1	33.3	0	1e+00	Epha6 Apeh
Pavlov. Cond. response bias	17.51	2	1	33.3	0	1e+00	Epha6 Apeh
Bone surface	4.16	1	0	0	0	1e+00	Epha6
Bone: cortical porosity	5.58	1	0	0	0	1e+00	Epha6
Bone: cortical thickness	13.93	1	0	0	0	1e+00	Epha6
Bone: maximum diameter	7.31	1	0	0	0	1e+00	Epha6
Bone: periosteal estimation	2.98	1	0	0	0	1e+00	Epha6
Bone: periosteal perimeter	4.91	1	0	0	0	1e+00	Epha6
Bone: stiffness	7.81	1	0	0	0	1e+00	Epha6
Time in open arm after self-admin	7.12	1	0	0	0	1e+00	Tcp11l1
Time to tail flick, test, before self-admin	6.51	1	0	0	0	1e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	8.08	1	0	0	0	1e+00	Epha6
Ambulatory time before self-admin	10.3	1	0	0	0	1e+00	Apeh
Total heroin consumption	5.1	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 0s delay	11.8	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 4s delay	9.29	1	0	0	0	1e+00	Epha6
Fecal boli incidents, locomotor time 1	6.68	1	0	0	0	1e+00	Tcp11l1
Time >=10cm from walls, locomotor time 1	6.04	1	0	0	0	1e+00	Epha6
Bouts of movement, locomotor time 1	7.86	1	0	0	0	1e+00	Epha6
Rest time, locomotor task time 1	6.8	1	0	0	0	1e+00	Tcp11l1
Rest time, locomotor task time 2	5.68	1	0	0	0	1e+00	Epha6
Seeking ratio, delayed vs. immediate footshock	11.18	1	0	0	0	1e+00	Epha6
Locomotion in novel chamber post-restriction	15.51	1	0	0	0	1e+00	Epha6
Latency to leave start box in cocaine runway	10.3	1	0	0	0	1e+00	Epha6
Cu content in liver	4.82	1	0	0	0	1e+00	Apeh
Na content in liver	9.4	1	0	0	0	1e+00	Epha6
Se content in liver	13.19	1	0	0	0	1e+00	Epha6

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.1
Adipose	alternative TSS	0	0	1.09
Adipose	gene expression	0	0	1.14
Adipose	isoform ratio	0	0	1.09
Adipose	intron excision ratio	0	0	1.12
Adipose	mRNA stability	0	0	1.11
BLA	alternative polyA	0	0	1.12
BLA	alternative TSS	0	0	1
BLA	gene expression	0	0	1.13
BLA	isoform ratio	0	0	1.16
BLA	intron excision ratio	0	0	1.08
BLA	mRNA stability	0	0	1.1
Brain	alternative polyA	0	0	1.18
Brain	alternative TSS	0	0	1.13
Brain	gene expression	0	0	1.12
Brain	isoform ratio	0	0	1.18
Brain	intron excision ratio	0	0	1.09
Brain	mRNA stability	0	0	1.13
Eye	alternative polyA	0	0	1.76
Eye	alternative TSS	0	0	1.08
Eye	gene expression	0	0	1.11
Eye	isoform ratio	0	0	1.23
Eye	intron excision ratio	0	0	1.08
Eye	mRNA stability	0	0	1.05
IL	alternative polyA	0	0	1.3
IL	alternative TSS	0	0	1.11
IL	gene expression	0	0	1.12
IL	isoform ratio	0	0	1.3
IL	intron excision ratio	0	0	1.14
IL	mRNA stability	0	0	1.19
LHb	alternative polyA	0	0	1.17
LHb	alternative TSS	0	0	1.33
LHb	gene expression	0	0	1.12
LHb	isoform ratio	0	0	1.24
LHb	intron excision ratio	0	0	1.13
LHb	mRNA stability	0	0	1.16
Liver	alternative polyA	0	0	1.16
Liver	alternative TSS	0	0	1.17
Liver	gene expression	0	0	1.12
Liver	isoform ratio	0	0	1.21
Liver	intron excision ratio	0	0	1.12
Liver	mRNA stability	0	0	1.15
NAcc	alternative polyA	0	0	1.12
NAcc	alternative TSS	0	0	1.06
NAcc	gene expression	0	0	1.14
NAcc	isoform ratio	0	0	1.14
NAcc	intron excision ratio	0	0	1.14
NAcc	mRNA stability	0	0	1.15
OFC	alternative polyA	0	0	1.27
OFC	alternative TSS	0	0	1.14
OFC	gene expression	0	0	1.16
OFC	isoform ratio	0	0	1.34
OFC	intron excision ratio	0	0	1.24
OFC	mRNA stability	0	0	1.1
PL	alternative polyA	0	0	1.17
PL	alternative TSS	1	0.1	1.21
PL	gene expression	0	0	1.14
PL	isoform ratio	0	0	1.19
PL	intron excision ratio	0	0	1.13
PL	mRNA stability	2	0.1	1.17