Hub : Traits

Condit. Reinf. lever reinforcers received

Pavlovian Conditioned Approach, conditioned reinforcement, number of lever reinforcers received during the 40 min session

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

1 loci · 1 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	154277716	156447903	3	1	2.19e-07	2.19e-07	1e+00	P2ry2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Tail length	3.2	3	0	0	1	5.06e-12	Mrpl48 P2ry2 Arap1
Mean time between licks in bursts	7.69	3	0	0	1	3.74e-13	Mrpl48 P2ry2 Arap1
Light reinforcement 1	4.12	3	0	0	-1	6.53e-12	Mrpl48 P2ry2 Arap1
Condit. Reinf. active minus inactive responses	13.19	3	0	0	1	8.42e-17	Mrpl48 P2ry2 Arap1
Condit. Reinf. active responses	17.49	3	0	0	1	7.03e-17	Mrpl48 P2ry2 Arap1
Condit. Reinf. inactive responses	11.24	3	0	0	1	6.03e-16	Mrpl48 P2ry2 Arap1
Condit. Reinf. lever presses	24.27	3	3	300	1	4.55e-15	Mrpl48 P2ry2 Arap1
Pavlov. Cond. lever latency	23.63	3	3	300	-1	7.98e-14	Mrpl48 P2ry2 Arap1
Pavlov. Cond. change in total contacts	19.09	3	3	300	1	4.57e-14	Mrpl48 P2ry2 Arap1
Pavlov. Cond. index score	16.34	3	0	0	1	1.64e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. latency score	14.64	3	0	0	1	2.94e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. lever contacts	24.71	3	3	300	1	1.89e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. magazine entry number	6.79	3	0	0	-1	3.34e-12	Mrpl48 P2ry2 Arap1
Pavlov. Cond. lever-magazine prob. diff.	15.24	3	0	0	1	2.46e-13	Mrpl48 P2ry2 Arap1
Pavlov. Cond. response bias	23.26	3	3	300	1	2.03e-13	Mrpl48 P2ry2 Arap1
Time in open arm before self-admin	7.27	3	0	0	-1	7.50e-09	Mrpl48 P2ry2 Arap1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	2	0.1	1.4
Adipose	alternative TSS	0	0	1.45
Adipose	gene expression	0	0	1.42
Adipose	isoform ratio	0	0	1.31
Adipose	intron excision ratio	0	0	1.24
Adipose	mRNA stability	1	0	1.44
BLA	alternative polyA	0	0	1.3
BLA	alternative TSS	0	0	1.65
BLA	gene expression	0	0	1.5
BLA	isoform ratio	0	0	1.34
BLA	intron excision ratio	0	0	1.42
BLA	mRNA stability	0	0	1.43
Brain	alternative polyA	0	0	1.45
Brain	alternative TSS	0	0	1.41
Brain	gene expression	0	0	1.44
Brain	isoform ratio	0	0	1.38
Brain	intron excision ratio	0	0	1.39
Brain	mRNA stability	0	0	1.46
Eye	alternative polyA	0	0	1.32
Eye	alternative TSS	0	0	1.33
Eye	gene expression	0	0	1.5
Eye	isoform ratio	0	0	1.75
Eye	intron excision ratio	0	0	1.5
Eye	mRNA stability	0	0	1.49
IL	alternative polyA	0	0	1.21
IL	alternative TSS	0	0	1.34
IL	gene expression	0	0	1.4
IL	isoform ratio	0	0	1.35
IL	intron excision ratio	0	0	1.37
IL	mRNA stability	0	0	1.36
LHb	alternative polyA	0	0	1.28
LHb	alternative TSS	0	0	1.24
LHb	gene expression	0	0	1.41
LHb	isoform ratio	0	0	1.34
LHb	intron excision ratio	0	0	1.29
LHb	mRNA stability	0	0	1.51
Liver	alternative polyA	4	0.3	1.46
Liver	alternative TSS	0	0	1.39
Liver	gene expression	0	0	1.43
Liver	isoform ratio	0	0	1.36
Liver	intron excision ratio	0	0	1.38
Liver	mRNA stability	0	0	1.46
NAcc	alternative polyA	0	0	1.38
NAcc	alternative TSS	0	0	1.35
NAcc	gene expression	0	0	1.46
NAcc	isoform ratio	0	0	1.37
NAcc	intron excision ratio	0	0	1.32
NAcc	mRNA stability	0	0	1.47
OFC	alternative polyA	0	0	1.18
OFC	alternative TSS	0	0	1.47
OFC	gene expression	0	0	1.45
OFC	isoform ratio	0	0	1.32
OFC	intron excision ratio	0	0	1.28
OFC	mRNA stability	0	0	1.47
PL	alternative polyA	0	0	1.28
PL	alternative TSS	0	0	1.56
PL	gene expression	0	0	1.44
PL	isoform ratio	0	0	1.36
PL	intron excision ratio	0	0	1.39
PL	mRNA stability	0	0	1.46